姜黄素磷脂复合物不同制剂对SD大鼠口服生物利用度的影响  

The bioavailability influence of oral curcumin-phospholipid complex preparations on SD rats

作　　者：吴先闯[1] 郝海军[2] 张永州[1] 宋晓勇[1] 刘瑜新[1] 张红芹 

机构地区：[1]河南大学淮河医院,河南开封475000 [2]上海医药工业研究院,上海200437 [3]国家中药制药工程技术研究中心,上海201203

出　　处：《中成药》2015年第10期2163-2166,共4页Chinese Traditional Patent Medicine

基　　金：河南省科技发展计划项目(144300510019)

摘　　要：目的比较姜黄素磷脂复合物以水分散体、固体分散体及油制剂形式给药时对SD大鼠口服吸收生物利用度的影响。方法 SD大鼠分别灌胃给予姜黄素磷脂复合物上述3种制剂,取血,以大黄素为内标,HPLC法测定姜黄素的血药浓度,并计算药动学参数。结果姜黄素磷脂复合物油制剂的曲线下面积(AUC0-∞)分别为原料药、水分散体及固体分散体的7.99、1.58和1.46倍,而且其tmax与t1/2也均有所延长。结论姜黄素磷脂复合物以油制剂给药时,可显著地提高其生物利用度,这可能与其在油中有更高的稳定性有关。AIM To study the bioavailability influence of oral preparations of curcumin-phospholipid complex（ including aqueous dispersion,solid dispersion and oil-based formulation） on SD rats. METHODS After each of three groups of SD rats was administered intragastrically with one of the three different preparations respectively,their blood samples were collected at different time intervals. The curcumin concentrations were detected by HPLC with emodin as the internal standard,and thus the pharmacokinetic parameters were calculated and obtained. RESULTS The AUC0- ∞for oil-based preparation of curcumin-phospholipid complex was 7. 99,1. 58 and 1. 46 times of the crude drug,aqueous dispersion and solid dispersion,respectively,their tmaxand t1 /2were also extended to some extent. CONCLUSION Manifesting a better stability in oil,the bioavailability of curcumin-phospholipid complex is greatly enhanced by oil-based preparation.

关 键 词：姜黄素 磷脂复合物 SD大鼠 生物利用度 水分散体 固体分散体 油制剂 

分 类 号：R285.5[医药卫生—中药学]