宫腔内人工授精促排卵周期中使用GnRha诱导卵泡成熟疗效观察  

Observation on the curative effect of using GnRhato inducematurationof follicle in the intrauterine inseminationovulationcycle

作　　者：连蔚[1] 李彩英[1] 罗一平[1] 梁美燕[1] 田小燕[1] 

机构地区：[1]广东省佛山市顺德第一人民医院辅助生育中心,528300

出　　处：《齐齐哈尔医学院学报》2015年第25期3777-3778,共2页Journal of Qiqihar Medical University

摘　　要：目的观察宫腔内人工授精促排卵周期中使用促性腺激素释放激素激动剂（GnRha）诱导卵泡成熟的疗效,探讨促性腺激素释放激素激动剂（GnRha）促进卵泡成熟对腔内人工授精临床结局的影响。方法选择2013年4月至2015年4月我院进行宫腔内人工授精促排卵的100例PCOS患者作为研究对象,将其随机分为应用促性腺激素释放激素激动剂（GnRha）诱导卵泡成熟为实验组（n=50）和应用绒毛膜促性腺激素（h CG）诱导卵泡成熟为对照组（n=50）。对照组患者在注射h CG后24~36小时内进行宫腔内人工授精,实验组患者在注射GnRHa后的24~36小时内进行宫腔内人工授精。比较对照组和观察组的排卵率、妊娠率及流产率。结果对照组和实验组患者的排卵率、妊娠率、流产率均未出现明显的差异,P〉0.05,差异不具有统计学意义。结论在宫腔内人工授精促排卵周期中使用GnRHA能够有效诱导卵泡成熟,其与h CG的促排卵效果接近,可替代h CG进行诱导排卵。Objective To observe the curative effect of using GnRhato inducematurationof follicle in the intrauterine inseminationovulationcycle,explore the influence of GnRha on clinical outcomes of intrauterine inseminationovulation. Methods 100 cases ofpatients received intrauterine inseminationovulation in our hospital during April2013 and April2015 were selected as researchobject,they were randomly divided intoexperimental group（ applied GnRha for induction offollicular maturation,n = 50） and control group（ applied HCGforinduction offollicular maturation,n = 50）. The patients of control groupreceivedintrauterine insemination within24 to36 hoursafter HCG injection,the patients in the experimental groupreceivedintrauterine insemination within24 to36 hoursafter injection of GnRha. Ovulation rate,pregnancy rate andabortion rate of the two groups were compared.Results The ovulation rate,pregnancy rate and abortion rateshowed no obviousdifference between controlgroup and the experimental group（ P〉0. 05）. Conclusions In intrauterine inseminationovulationcycle using GnRhacan effectively inducefollicular maturation,andclose totheovulationeffect of HCG,it can substitute HCG forovulation induction.

关 键 词：促性腺激素释放激素激动剂 绒毛膜促性腺激素 PCOS 宫腔内人工授精 促排卵 诱导卵泡成熟 疗效 

分 类 号：R711.6[医药卫生—妇产科学]