血清总胆红素联合溶血三项试验检测在新生儿溶血病早期诊治中应用价值分析  

Analyzing the application value of detection of serum total bilirubin and hemolysis test in diagnosing hemolytic disease of the newborn

作　　者：张少丰[1] 叶长钦[1] 陈楚填[1] 李文忠[1] 尹艳丹[1] 方焕仪[1] 

机构地区：[1]东莞市厚街医院,广东523945

出　　处：《齐齐哈尔医学院学报》2015年第25期3816-3817,共2页Journal of Qiqihar Medical University

摘　　要：目的分析血清总胆红素联合溶血三项试验在新生儿溶血病早期诊治中的应用价值。方法以我院2013年1—12月收治的100例新生儿(母亲血型均为O型)为研究对象,均表现为高胆红素血症,对其行溶血三项试验(抗体放散试验、直接抗人球蛋白试验及游离抗体试验),根据试验阳性率分为四组,对所有患儿经蓝光光疗、丙种球蛋白静脉注射等治疗,通过全自动生化分析仪测定比较各组治疗前后血清总胆红素水平。结果 100例新生儿中,A组16例,B组6例,C组49例,D组29例。四组患儿治疗后血清总胆红素较治疗前明显下降,差异有统计学意义(P<0.05)。治疗前四组患儿血清总胆红素水平:A组>C组>B组>D组,组间比较差异无统计学意义(P>0.05)。结论溶血三项试验联合血清总胆红素检测有利于新生儿溶血病早期诊断、治疗。Objective To analyze the application value of detecting serum total bilirubin combined with hemolysis test in diagnosing hemolytic disease of the newborn. Methods 100 cases of newborn（ whose mother＇s blood type were O） treated in our hospital during January 2013 and December 2013 were chose as research object,all of them with the disease of hyperbilirubinemia,and all of them received three hemolysis experiments（ antibody elution test,direct anti- globulin test and free antibody test）. They were divided into four groups according to the positive rate. The patients underwent blue light phototherapy,intravenous immunoglobulin treatment. Total bilirubin level in serum was detected by automatic biochemical analyzed instrument. Results Among the 100 cases of newborns,16 cases in group A,6 cases in group B,49 cases in group C,29 cases in group D. The total bilirubin in serum of four groups after treatment were significantly decreased than that before treatment,the differences were statistically significant（ P〈0. 05）. Total bilirubin levels in serum of four groups before treatment decreased as the range： group A,group C,group B and group D,the differences among the groups had no significant（ P〉0. 05）. Conclusions The combination detection of total bilirubin in serum and hemolytic three test is conducive to early diagnosis,treatment of hemolytic disease of the newborn.

关 键 词：溶血三项试验 血清总胆红素 新生儿溶血病 早期诊治 

分 类 号：R722.18[医药卫生—儿科]