血浆N末端脑钠肽原及降钙素原在川崎病中的应用  

作　　者：蔡素芬[1] 邹峥[1] 彭宇[1] 

机构地区：[1]江西省儿童医院风湿免疫科,江西330006

出　　处：《当代医学》2015年第29期6-8,共3页Contemporary Medicine

摘　　要：目的探讨血浆N末端脑钠肽原(N-pro-BNP)及降钙素原在早期诊断川崎病及预测其心血管损害中的意义。方法选取46例川崎病患儿作为观察组,并根据患儿的心脏彩超及心电图结果进行分组,将其分为心血管损害组和无心血管损害组。同时选取健康体检儿童21名作为正常对照组。采集各组血清,采用化学发光法技术测定血浆N末端脑钠肽原及降钙素原的表达水平。结果川崎病患儿血浆中BNP水平为(710.526±757.668)ng/m L,而对照组患儿血浆中BNP水平为(66.226±18.443)ng/m L,川崎病患儿血浆中N末端脑钠肽的水平显著高于对照组(P<0.05)。川崎病患儿血浆中PCT水平为(2.677±8.165)ng/m L,而对照组患儿血浆中PCT水平为(0.208±0.085)ng/m L,川崎病患儿血浆中PCT水平显著高于对照组(P<0.05)。在川崎病患儿中,心血管损害组的BNP水平为(1345.785±534.590)ng/m L,无心血管损害组的BNP水平为(167.812±75.644)ng/m L,心血管损害组患儿血浆中BNP水平显著高于无心血管损害组(P<0.05);心血管损害组的PCT水平为(4.250±11.388)ng/m L,无心血管损害组的PCT水平为(0.771±2.092)ng/m L,心血管损害组患儿PCT水平显著高于无心血管损害组(P<0.05)。结论血浆N末端脑钠肽原及降钙素原在早期诊断川崎病及预测心血管损害方面有重要的意义,为诊断川崎病及时使用丙种球蛋白提供理论依据,以减少川崎病患儿冠状动脉的损害,保护患儿身心健康。Objective To explore the expression of N-pro-BNP and PCT in kawasaki disease,and discuss their significance value in the coronary artery lesion（CLA） with kawasaki disease.Methods 46 cases of KD were drawn as observation group, in which 24 patients developed with coronary artery lesion, other 23 patients with normal coronary artery. Meanwhile, 21 normal cases were selected as normal control group. Blood samples were collected. BNP and PCT levels were detected by chemiluminescence. We analyzed all the data with SPSS 20.0 for Windows.Results The mean plasma BNP concentration in patients with KD was（710.526±757.668）ng/mL, but was （66.226±18.443）ng/mL in patients of control. The plasma BNP contention in patients with KD was significantly higher than that of the control group（P〈0.05）. The mean PCT concentration in patients with KD was（2.677±8.165）ng/ml, and was（0.208±0.085）ng/mL in patients of control. The plasma PCT contention in patients with KD was significantly higher than that of the control group（P〈0.05）.During the KD group, patients developed with coronary artery lesion. The leavel of BNP in patients with coronary artery lesion was（1345.785±534.590）ng/mL, but was （167.812±75.644）ng/mL in patients with normal coronary artery. The plasma BNP leavel in patients with coronary artery lesion was much higher than patients with normal coronary artery （P〈0.05）. The leavel of PCT in patients with coronary artery lesion was（4.250±11.388）ng/mL, but was（0.771±2.092）ng/mL in patients with normal coronary artery. The plasma PCT leavel in patients with coronary artery lesion was much higher than patients with normal coronary artery （P〈0.05）.Conclusion The plasma BNP and PCT may be useful in the early diognosis of KD, the level of plasma BNP and PCT can be used as biochemical marker of cardiac involvernent. This would be valuable for the diagnosis of KD, which would decrease the probability of coronary artery lesion.

关 键 词：N末端脑钠肽原 降钙素原 川崎病 

分 类 号：R725.4[医药卫生—儿科]