绞股蓝总皂苷自微乳化给药系统的制备  

Preparation of gypenoside self- microemulsifying drug delivery system

作　　者：钟婉华[1] 刘丹霞[1] 崔升淼[1] 

机构地区：[1]广东药学院中药学院,广东广州510006

出　　处：《药学研究》2015年第11期654-657,678,共5页Journal of Pharmaceutical Research

基　　金：广东药学院2014年国家级大学生创新创业训练计划项目(No.201410573008)

摘　　要：目的绞股蓝总皂苷自微乳化给药系统的制备及评价。方法通过溶解度试验、伪三元相图及星点设计-效应面法,以粒径、Zeta电位、自微乳化时间为指标,筛选最佳处方,并对绞股蓝总皂苷自微乳化给药系统体外释药进行测定。结果绞股蓝总皂苷自微乳的最优处方为:吐温-80 52%,甘油30%,油酸乙酯26%;其平均粒径为51.21 nm,Zeta电位为-13.7 m V,乳化时间为31.54 s,在45 min的体外溶出度是原料药的5倍。结论绞股蓝总皂苷自微乳化给药系统制备工艺可行,能显著提高绞股蓝总皂苷的溶出度。Objective To prepare gypenoside self- microemulsifying drug delivery system( SMEDDS) and evaluate its quality. Methods The optimized formulation of gypenoside SMEDDS was screened by solubility,ternary phase diagrams and central composite design- response surface method with the particle size,the Zeta potential and the time of self- emulsification as parameters. The physic- chemical property and dissolution characters of gypenoside SMEDDS were also determined. Results The optimized formulation was composed of tween- 80( 52%),glycerol( 30%),ethyl oleate( 26%). The average particle size after the emulsification was 51. 21 nm,the Zeta potential- 13. 7 m V,the time of self- emulsification was 30. 54 s. The percent of accumulated dissolution of gypenoside in SMEDDS in vitro was 5 times of crude material at 45 min. Conclusion The preparation method of gypenoside SMEDDS was feasible,which can significantly increase the dissolution of gypenoside.

关 键 词：绞股蓝总皂苷 自微乳化给药系统 伪三元相图 星点设计 效应面法 

分 类 号：R944[医药卫生—药剂学]