ALX-R和NF-κBp65在口腔扁平苔藓病灶中的表达研究  

Study on expression of lipoxin A4 receptor and nuclear factor-κbp65 in lesions of oral lichen planus

作　　者：宋典坤[1] 关为群[1] 王学莹[1] 刘瑜佳 

机构地区：[1]福建医科大学附属协和医院,福建福州350001

出　　处：《现代医药卫生》2015年第20期3050-3052,3055,共4页Journal of Modern Medicine & Health

基　　金：福建省自然科学基金面上项目(2013J01314)

摘　　要：目的通过检测脂氧素A4受体(ALX-R)及核因子-κBp65(NF-κBp65)在口腔扁平苔藓(OLP)病灶黏膜中的表达情况,探讨二者在OLP发病机制中的可能作用。方法采用免疫组化法检测30例OLP组织(糜烂型OLP组16例,非糜烂型OLP组14例)与10例正常口腔黏膜组织(对照组)中ALX-R和NF-κBp65蛋白的表达情况。结果(1)ALX-R蛋白,在糜烂型与非糜烂型OLP组织中表达阳性率比较,差异无统计学意义(P>0.05);OLP组织中,糜烂型组NF-κBp65蛋白表达阳性率高于非糜烂型组,差异有统计学意义(P<0.05);(2)OLP组ALX-R蛋白表达阳性率低于对照组,NF-κBp65蛋白表达阳性率高于对照组,差异均有统计学意义(P<0.01);(3)OLP组和对照组中ALX-R与NF-κBp65的蛋白表达均呈负相关(r=-1,P<0.01)。结论 ALX-R与NF-κBp65表达异常可能与OLP的发病机制密切相关。Objective To detect the expression of lipoxin A4 receptor（ALX-R） and the transcription nuclear factor KBp65 （NF-κBp65） in oral mucosal lesion of the patients with oral lichen planus （OLP） and to investigate their possible roles in the patho- genesis of OLP. Methods Immunohistochemistry was adopted to detect the expression of ALX-R and NF-κBp65 protein in the oral mucosa of 30 OLP patients （including 16 cases of erosive type and 14 cases of non-erosive type） and 10 cases of normal oral mucosa （control group）. Results （1）The positive rate of ALX-R protein expression had no statistical difference between the ero- sive type OLP tissue and the non-erosive type OLP tissue （P〉0.05） ;in OLP oral mucosa tissue, the positive rate of NF-κBp65 pro- tein expression in the erosive type group was higher than that in the non-erosive type group ,the difference was statistically signifi- cant （P〈0.05） ; （2）the positive rate of ALX-R protein expression in the OLP group was lower than that in the control group （P〈0.05）, but the positive rate of NF-κBp65 protein expression in the OLP group was significantly higher than that in the control group ,the difference was statistically significant （P〈0.01） ; （3）the ALX-R protein expression in the OLP group and the control group was negatively correlated with the NF-κBp65 protein expression=-1, P〈0.01 ）. Conclusion The abnormal expressions of ALX-R and NF-KBp65 in oral mucosa may be closely related with the pathogenesis of OLP.

关 键 词：扁平苔癣 口腔 受体 细胞表面 脂氧素类 NF-ΚB 免疫组织化学 

分 类 号：R59[医药卫生—内科学]