血浆置换及静脉注射免疫球蛋白治疗格林巴利综合征临床研究  

Clinical study on plasmapheresis and intravenous immunoglobulin in treating Guillain-Barre syndrome

作　　者：王丹[1] 郭珍立[1] 任敏[2] 曾可斌[2] 

机构地区：[1]湖北省新华医院神经内科,武汉430015 [2]重庆医科大学附属第一医院神经内科,重庆400016

出　　处：《现代医药卫生》2015年第20期3062-3064,3066,共4页Journal of Modern Medicine & Health

摘　　要：目的对比研究小剂量血浆置换(SVP)、大剂量血浆置换(LVP)及静脉注射免疫球蛋白(IVIG)治疗格林巴利综合征(GBS)的临床效应。方法对重庆医科大学附属第一医院2008年6月至2014年6月收治的75例GBS住院患者,根据患者自愿选择及血浆来源分为SVP组(41例)、LVP组(8例)和IVIG(26例)进行治疗,并对患者的临床资料、疗效及不良反应进行分析比较。结果 SVP、LVP、IVIG组总有效率分别为90.2%、87.5%、92.3%,三组比较,差异无统计学意义(χ2=0.91,P=0.186),但SVP组住院时间较长,LVP组不良反应发生率较高,三组患者住院时间、不良反应发生率比较,差异均有统计学意义(P<0.05)。结论 SVP、LVP和IVIG都是目前治疗GBS的有效方法,早期治疗可以明显改善预后。三者疗效无显著差异。Objective To compare the clinical effects of small dose of plasma exchange （SVP） ,high-dose plasma ex- change （LVP） and intravenous immunoglobulin（IVIG） in treating Guillain-Barre syndrome（GBS）. Methods 75 GBS inpatients in the First Affiliated Hospital of Chongqing Medical University from June 2008 to June 2014 were randomly assigned to the SVP group （41 cases）, LVP group （8 cases） and I^IG group （26 cases） according to the voluntary choice and plasma sources. Then the clinical data, efficacy and adverse reactions in 3 groups were analyzed. Results The total effective rates in the SVP group, LVP group and IVIG group were 90.2%, 87.5% and 92.3% respectively ,the differences were not statistically significant （X2=0.91 ,P= 0.186）, but the SVP group had longer hospitalization duration and the LVP group had higher occurrence rate of adverse reactions, the hospitalization duration and the occurrence rate of adverse reactions had statistical difference among 3 groups（P〈0.05 ）. Con- clusion SVP, LVP and IVIG all are the effective way for treating GBS at present. Early treatment can significantly improve the prognosis. The three kinds of therapy have no significant difference in the curative effects.

关 键 词：血浆置换 免疫球蛋白类 输注 静脉内 格林.巴利综合征 自身免疫疾病 多发性神经根神经病 

分 类 号：R979.5[医药卫生—药品]