河南省健康人群水痘-带状疱疹病毒抗体水平调查  

Serum level of varicella-zoster virus antibody among healthy residents in Henan province

作　　者：赫欣[1] 刘畅[1] 崔明辰[1] 李宁霞 刘国良[1] 张晓明 刘俊英[4] 

机构地区：[1]漯河医学高等专科学校预防医学教研室,河南漯河462000 [2]漯河市第一人民医院检验科 [3]漯河市召陵区中心医院检验科 [4]周口市中心医院内科

出　　处：《中国公共卫生》2015年第10期1301-1303,共3页Chinese Journal of Public Health

基　　金：河南省科技攻关计划项目(102102310431);河南省教育厅高等学校骨干教师资助项目(教高[2010]862号287)

摘　　要：目的 了解河南省健康人群水痘-带状疱疹病毒（VZV）抗体水平,为制定水痘和带状疱疹的防控策略提供理论依据。方法 采用分层随机抽样方法对在河南省郑州、漯河、周口地区抽取的654名1-70岁健康人群进行血清标本采集,并应用酶联免疫吸附试验测定VZV-Ig G抗体。结果 河南省健康人群中血清VZV-Ig G抗体阳性率为70.64%,抗体平均滴度为（1 834.05±246.71）m U/m L;1-3、4-6、7-13、14-20、21-35、36-45、46-60和61-70岁健康人群VZV-Ig G抗体阳性率分别为23.44%、35.89%、70.73%、88.75%、95.40%、97.78%、80.68%和56.47%,抗体平均滴度分别为（90.11±24.37）、（168.64±50.19）、（700.18±193.55）、（1 275.77±352.78）、（2412.48±591.76）、（2 795.21±644.25）、（3 116.35±610.57）和（2 537.84±551.40）m U/m L,抗体阳性率和抗体平均滴度均随年龄增长呈先升高后降低的趋势（均P=0.000）;各年龄组不同性别人群抗体阳性率和抗体平均滴度比较,差异均无统计学意义（均P〉0.05）;郑州、漯河和周口地区健康人群VZV-Ig G抗体阳性率分别为75.64%、72.42%和60.43%,抗体平均滴度分别为（2 436.15±847.76）、（2 294.03±645.58）和（1 538.37±306.84）m U/m L,不同地区健康人群抗体阳性率和抗体平均滴度差异均有统计学意义（均P=0.000）。结论 河南省健康人群血清VZV-Ig G抗体水平较高,〈7岁儿童和〉60岁老年人是水痘-带状疱疹的高危人群。Objective To investigate serum level of varicella-zoster virus （VZV） antibody among healthy residents in Henan province and to provide theoretical basis for making VZV infection control strategies. Methods With stratified random sampling ,654 healthy residents aged 1 -70 years were recruited from urban and rural areas of 3 municipalities in Henan province and their blood samples were collected to detect serum VZV antibody using enzyme-linked immunosor- bent assay（ELISA）. Results The overall positive rate of serum VZV-specific immunoglobulin G （IgG）was 70. 64% and the average titer of serum VZV-IgG was 1 834. 05 ±246. 71 mU/mL. Both the positive rate and the average titer of VZV-IgG increased first and then decreased with the increment of age, with the positive rates of 23.44% , 35.89% , 70. 73% ,35.89% ,95.40% ,97.78% ,80. 68% ,and 56. 47% and the average titers of 90. 11 ±24.37,168.64 ±50. 19, 700. 18 ± 193.55,1 275.77 ± 352. 78,2 412.48 ± 591.76,2 795.21 ± 644. 25,3 116. 35 -± 610. 57, and 2 537.84 ± 551.40 mU/mL for the participants aged 1 -3,4 -6,7 -13,14 -20,21 -35,36-45,46 -60,and 61 -70 years,respectively. No significant gender-difference in the positive rate and average titer was observed among the participants of various age groups; but there were statistically significant differences in the positive rate and the average titer among the participants from different municipalities. Conclusion The positive rate of serum VZV antibody is relatively high among healthy residents in Henan province, especially among those aged less than 7 years and older than 60 years.

关 键 词：水痘-带状疱疹病毒(VZV) 抗体水平 健康人群 

分 类 号：R511.5[医药卫生—内科学]