Development of glutamatergic innervation during maturation of adult-born neurons  

作　　者：Cristina V. Dieni Adam J. Wieckert Linda Overstreet-Wadiche 

机构地区：[1]Department of Neurobiology and Evelyn McKnight Brain Institute, University of Alabama at Birmingham,Birmingham, AL 35294, USA

出　　处：《Frontiers in Biology》2015年第4期310-320,共11页生物学前沿（英文版）

摘　　要：The dentate gyrus is the entrance of the hippocampal formation and a primary target of excitatory afferents from the entorhinal cortex that carry spatial and sensory information. Mounting evidence suggests that continual adult neurogenesis contributes to appropriate processing of cortical information. The ongoing integration of adult born neurons dynamically modulates connectivity of the network, potentially contributing to dentate cognitive function. Here we review the current understanding of how glutamatergie innervation develops during the progression of adult-born neuron maturation. Summarizing the developmental stages of dentate neurogenesis, we also demonstrate that new neurons at an immature stage of maturation begin to process afferent activity from both medial and lateral entorhinal cortices.The dentate gyrus is the entrance of the hippocampal formation and a primary target of excitatory afferents from the entorhinal cortex that carry spatial and sensory information. Mounting evidence suggests that continual adult neurogenesis contributes to appropriate processing of cortical information. The ongoing integration of adult born neurons dynamically modulates connectivity of the network, potentially contributing to dentate cognitive function. Here we review the current understanding of how glutamatergie innervation develops during the progression of adult-born neuron maturation. Summarizing the developmental stages of dentate neurogenesis, we also demonstrate that new neurons at an immature stage of maturation begin to process afferent activity from both medial and lateral entorhinal cortices.

关 键 词：dentate gyms adult neurogenesis glutamatergic innervation granule cell neuroprogenitor 

分 类 号：Q426[生物学—神经生物学] TS252.53[生物学—生理学]