Synthesis of 2-Hydroxymalononitrile  

作　　者：YANG Jianxin YIN Yunxing HE Zhenmin ZHANG Zhiliu LIN Xiaojuan MA Rujian 

机构地区：[1]Tianjin Key Laboratory for Modern Drug Delivery & High-Efficiency, School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, P. R. China [2]Wuxi PharmaTech Co., Ltd., Shanghai 200131, P. R. China

出　　处：《Chemical Research in Chinese Universities》2015年第5期685-687,共3页高等学校化学研究（英文版）

基　　金：Supported by the National Natural Science Foundation of China（No.51209024）.

摘　　要：α-Hydroxyl carboxylic acids and their derivatives exist as the key substructures in a variety of biologically active natural products and numerous pharmaceuticals. Various -COX synthons（X=OH, or the equivalent）, which are useful umpolung agents, have been developed. Recently, Nemoto et al. prepared the masked acyl cyanides[2, HC（CN）2OR3],α-COX synthon that played an important role in the synthesis of a-hydroxyl carboxylic acids and their derivatives, from commercially available materials in three steps under mild conditions（Scheme 1）.α-Hydroxyl carboxylic acids and their derivatives exist as the key substructures in a variety of biologically active natural products and numerous pharmaceuticals. Various -COX synthons（X=OH, or the equivalent）, which are useful umpolung agents, have been developed. Recently, Nemoto et al. prepared the masked acyl cyanides[2, HC（CN）2OR3],α-COX synthon that played an important role in the synthesis of a-hydroxyl carboxylic acids and their derivatives, from commercially available materials in three steps under mild conditions（Scheme 1）.

关 键 词：α-Hydroxyl ester One-pot synthesis 2-Hydroxymalononitrile 

分 类 号：O621.3[理学—有机化学] TS74[理学—化学]