急性心肌梗死患者血清胎盘生长因子与近期心功能的关系  

Relationship between serum placenta growth factor and recent cardiac function in patients with acute myocardial infarction

作　　者：张惠军[1] 郭喜朝[1] 彭启华[1] 武彤[1] 夏杨[1] 张晶[2] 李贺[2] 

机构地区：[1]武警北京总队医院内四科,北京100027 [2]武警后勤学院附属医院,天津300162

出　　处：《武警后勤学院学报（医学版）》2015年第9期700-702,共3页Journal of Logistics University of PAP（Medical Sciences）

摘　　要：【目的】连续检测急性心肌梗死(acute myocardial infarction,AMI)后循环胎盘生长因子(placental growth factor,Pl GF)、心肌损伤标志物变化,分析与MI后近期左心室功能的关系,探讨其临床意义。【方法】入选90例AMI患者,检测发病12 h、第3、7天循环Pl GF及心肌肌钙蛋白(cardiac troponin I,c Tn I)水平,30 d后行超声心动图左心室功能检查。【结果】与正常对照组比较,(1)AMI组发病12 h、3 d循环PIGF显著增高(P<0.05),7 d恢复至对照组水平(P>0.05),相同时间点循环c Tn I均显著增高(P<0.05)。(2)MI后30 d左心室功能指标:左心室舒张末期容积(left ventricular end diastolic volume,LVEDV)、左心室舒张末期内径(left ventricular end diastolic diameter,LVEDD)、左心室射血分数(left ventricle ejection fraction,LVEF)与正常对照组无明显差异。(3)Pl GF、c Tn I分别与LVEDV(r=0.854,P<0.01、r=0.547,P<0.01)、LVEDD呈显著正相关(r=0.684,P<0.01、r=0.515,P<0.01),与LVEF呈显著负相关(r=-0.654,P<0.01、r=-0.358,P<0.01)。【结论】AMI后早期循环Pl GF、c Tn I水平均与MI近期心功能变化相关,Pl GF增加可能有利于近期心功能恢复。【Objective】To continuously detect the changes of circulatory placenta growth factor（PlGF） and markers of myocardial damage after acute myocardial infarction（AMI）, analyze their relationship and explore the clinical significance.【Methods】90 AMI patients participated in the study. Circulatory PlGF and cardiac troponin I（cTnI） were detected on the 12 th hour, 3rd and 7th day; echocardiography was performed for left ventricular function about 30 days after the onset of myocardial infarction.【Results】Compared with the control group,（1） in AMI group, circulatory PlGF rose obviously on the 12 th hour and 3rd day（P〈0.05）, and went back to the control level on the 7th day（P〉0.05）. While circulatory cTnI all increased significantly on the same timepoint（P〈0.05）.（2） 30 days after MI, left ventricular function indexes showed no obvious difference, such as left ventricular end diastolic volume（LVEDV）, left ventricular end diastolic diameter（LVEDD）, left ventricular ejection fraction（LVEF）.（3） PlGF and cTnI peak value were negatively correlated with the early phase left ventricular ejection fraction（LVEF）, positively correlated with both left ventricular end diastolic volume（LVEDV） and LVEDD.【Conclusions】Early-phase levels of circulatory PlGF and cTnI after AMI are correlated with the recent cardiac function,and Circulatory PlGF and cTnI levels of AMI early-physae are correlated with the recent cardiac function, and PlGF may contribute to improve cardiac function.

关 键 词：急性心肌梗死 胎盘生长因子 肌钙蛋白I 心功能 

分 类 号：R541.4[医药卫生—心血管疾病]