龙骨牡蛎不同剂量配比的适用性模型构建研究——基于博弈论模型构建的海洋中药药对研究思路与方法  

Applicability Study of Long-Gu and Mu-Li Model Establishment under Different Dosages and Matching-Thoughts and Methods of Marine Medicine Herb Pairs Based on Game Theory Model Establishment

作　　者：王慧美[1] 王安娜[1] 韩雅丽[2] 王振国[3] 付先军[3] 

机构地区：[1]山东中医药大学基础医学院,济南250014 [2]山东中医药大学中医医史文献学泰山学者工作室,济南250355 [3]山东中医药大学信息管理学院中医文献研究所,济南250355

出　　处：《世界科学技术-中医药现代化》2015年第7期1327-1335,共9页Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology

基　　金：教育部高等学校博士学科点专项科研基金项目(20123731120001):基于方剂文献文本挖掘和关联网络的海洋中药用药经验模式研究;负责人:付先军;科学技术部国家高技术研究发展计划("863计划")项目(2013AA093001):海洋传统药源生物资源挖掘整理研究;负责人:王长云;山东省人力资源和社会保障厅博士后创新项目(201102036):基于"性-效-物质"三元理论的海洋中药复方有效组分配伍治疗慢性支气管炎的细胞分子机制研究;负责人:付先军

摘　　要：海洋中药是祖国中药宝库中的重要组成部分,是海洋经济发展的重要增长点之一。研究量效确切的海洋中药配伍,扩大海洋中药的临床应用,是现阶段海洋中药研究面临的重大问题。论文提出"文献检索-提取关于海洋中药方剂医案-建立医案数据库-数理统计与数据挖掘-构建药对博弈模型-研究固定剂量配比的药对功用"的研究构想,探索结合博弈理论研究海洋中药药对的新思路。通过文献检索和文本提取,获得应用龙骨牡蛎药对的病案458例,构建了合伙人博弈模型,采用严格下策反复消去法迭代剔除次优策略,假设龙牡等量使用且剂量30 g时为最佳策略,趋近纳什均衡。结果显示,30、25、24、20、18、15 g龙牡等量的剂量为可理性化的策略;30 g等量使用次数为数理统计频次之最;30 g龙牡等量使用时多取其重镇潜敛之功,对眠差、纳少、畏寒、耳鸣、神疲乏力、自汗盗汗等症状有治疗作用。关联规则分析、数理统计、博弈模型三方结果互为验证和补充,说明运用数理统计和数据挖掘技术、结合博弈论理论研究海洋中药药对思路具有可行性。Marine medicine is an important part of Chinese medicine and a growth point of marine economy development.Exploration on the exact weight ratios and curative effect to expand marine medicine clinical application is a significant issue in marine medicine research at this stage. This paper presented a research supposition of“documents retrieval, extraction of marine medicine cases, establishment of case database, statistic analysis, data mining, herb pair Game Theory model establishment, herb pair usage under fixed dosage and matching, in order to explore a new idea of researching marine medicine combined with Game Theory. Through the literature retrieval and text extraction, 458 cases with the herb pair ofLong-Gu （LG） andMu-Li（ML） were received to establish the partnership game model. The iterative removals of strictly dominated strategies were adopted. Assuming that LG and ML used with an equal amount of 30 g was the best response, which reached the Nash equilibrium. The results suggested that dosages of LG and ML used equally at the amount of 30 g, 25 g, 24 g, 20 g, 18 g, 15 g were rationalizable strategies. Frequencies of using an equal amount of 30 g LG and ML was the most of mathematical statistics. LG and ML of 30 g were used equivalently to treat symptoms such as insomnia, inappetence, chills, tinnitus, physically and mentally fatigued, spontaneous sweating and night sweating, and so on with the effect of tranquilizing and constricting. The results can be validated and complemented among association rules analysis, mathematical statistics and game model. It implied that it was feasible to apply mathematical statistics and data mining in combination with Game Theory to study the marine medicine herb pair.

关 键 词：博弈论 海洋中药 药对 龙骨牡蛎 关联规则 

分 类 号：R931.77[医药卫生—生药学]