从改善睡眠作用研究四逆散的疏肝解郁功效  

Correlation Study between Soothing Liver-qi Stagnation by Si-Ni-San and Effect of Improving Sleep

作　　者：李廷利[1] 

机构地区：[1]黑龙江中医药大学药学院,哈尔滨150040

出　　处：《世界科学技术-中医药现代化》2015年第7期1367-1371,共5页Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology

基　　金：国家自然科学基金委面上项目(30672634):四逆散治疗失眠的药效物质基础及作用机制研究;负责人:李廷利;国家自然科学基金委面上项目(81073077):四逆散有效组分的改善睡眠作用机理与体内代谢过程的研究;负责人:李廷利

摘　　要：对四逆散的改善睡眠作用进行药理学评价,深入研究四逆散疏肝解郁功效的科学内涵。以大鼠、小鼠和果蝇为模式生物,利用行为药理学、皮层脑电描记与分析、生物化学及分子生物学等实验方法与技术,开展四逆散改善睡眠作用的药理评价。四逆散能延长戊巴比妥钠所致小鼠睡眠时间,其作用存在着量效与时效关系;能延长正常或睡眠剥夺大鼠的慢波睡眠时间;对正常或睡眠剥夺大鼠脑中的多种神经递质、睡眠相关因子等均有影响。四逆散具有改善睡眠的作用,该作用与其疏肝解郁功效密切相关,是通过多途径、多靶点来实现的。Pharmacological evaluation on the improvement of sleeping effect usingSi-Ni-San（SNS） in order to conduct further study on scientific connotation of soothing liver-qistagnation. Rats, mice and fruit flies were used as animal model. Pharmacological assessment was conducted and done on the improvement of sleep effect by SNS with the cortical EEG scanning and analysis, biochemistry, molecular pharmacological methodology and technology. SNS can prolong the sleeping time of mice which were induced by pentobarbital sodium. Its effect showed the dose-dependent and time-dependent manner. It can prolong the slow-wave sleep time in normal and sleep deprivation rats. It influenced several neurotransmitters and endogenous sleep factors in brain of normal and sleep deprivation rats. SNS can improve sleeping. The effect was closely related the effect of soothing liver-qi stagnation. The function was realized through multiple pathways and targets.

关 键 词：四逆散 睡眠 药理评价 疏肝解郁 

分 类 号：R277.7[医药卫生—中医学]