基于信息计量与关联网络的海洋中药研究文献分析  

Literature Analysis of Marine Medicine Based on Information Bibliometrics and Associate Network Methods

作　　者：韩雅丽[1] 张丰聪[1,2] 付先军[1,2] 王振国[1,2] 李学博[1,2] 

机构地区：[1]山东中医药大学中医医史文献学泰山学者工作室,济南250355 [2]山东中医药大学信息管理学院/中医文献研究所,济南250355

出　　处：《世界科学技术-中医药现代化》2015年第7期1425-1431,共7页Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology

基　　金：科学技术部国家重点基础研究发展计划("973计划")项目(2007CB512601):基于四性的中药性-效-物质关系研究;负责人:王振国;科学技术部国家高技术研究发展计划("863计划")项目(2013AA093001):海洋传统药源生物资源挖掘整理研究;负责人:王长云;教育部高等学校博士学科点专项科研基金项目(20123731120001):基于方剂文献文本挖掘和关联网络的海洋中药用药经验模式研究;负责人:付先军;山东省人力资源和社会保障厅博士后创新项目(201102036):基于"性-效-物质"三元理论的海洋中药复方有效组分配伍治疗慢性支气管炎的细胞分子机制研究;负责人:付先军;国家自然科学基金委面上项目(81473369):基于"性-构"关系的中药成分寒热药性评价;负责人:付先军

摘　　要：目的:分析近20年国内海洋中药研究概况,总结研究热点、特征规律,探讨发展趋势,为海洋中药的临床应用和进一步研发提供数据基础和科学依据。方法:以中国知识基础设施工程(China National Knowledge Infrastructure,CNKI)数据库作为资料来源,用信息计量学方法对相关文献进行分析,并用Cytoscape 3.1.1软件对高频关键词进行关联网络分析。结果:582篇文献纳入分析,2010-2014年5年间发表量达260篇,年均52篇,受各类基金资助的期刊文献266篇,载文最多的杂志是《中国海洋药物》,有278家机构从事相关研究,中国海洋大学是最高产机构,发文量在5篇以上的有12人,海洋药物、化学成分、海洋天然产物、指纹图谱、抗肿瘤等是出现频率较高的关键词。结论:近几年海洋中药研究逐渐成为中药科研领域的热点,研究的主体机构与核心作者群已初步形成。但研究大部分集中在天然产物和药理作用等方面,传统中药理论指导下的海洋中药研究起步较晚,研究基础薄弱,阻碍了海洋中药应拓展的临床应用。应拓展中医古籍文献的知识发现研究,建立海洋中药组方数据库,挖掘海洋中药方剂配伍规律,构建符合海洋中药性效特点的用药经验模式,为临床应用和养生保健提供科学依据。This study was aimed to analyze the research status of marine medicine in China. The research hot issues and feature rules were summarized in order to discuss development trends for the clinic application and further development of marine medicine in recent 20 years. The CNKI library was used as a source to retrieve literatures on marine medicine. The bibliometric methods and Cytoscape 3.1.1 were used to analyze. The results showed that 582 papers were included. A total of 260 papers were published during 2010 to 2014. And 52 papers were published annually. 266 papers in this field were funded. The papers were mostly published in theChinese Journal of Marine Drugs. A total of 278 research institutes were engaged in the research. And the institute published the most paper was the Ocean University of China. There were 12 researchers who had published more than 5 articles. This study focused on the keywords with highly frequency, which were marine drugs, chemical composition, marine natural products, fingerprints and antitumor. It was concluded that marine medicine had become hot issues. The core of the group has been formed. However, most researches had focused on natural products and pharmacological aspects. Traditional Chinese medicine （TCM） theory had not been taken seriously and the infrastructure was weak, which obstructed the clinical application of marine medicine. We should expand the discovery and study of knowledge on ancient herbal literature as well as clinic application of marine medicine in order to build the knowledge database of marine medicine and experience mode of clinic application.

关 键 词：海洋中药 信息计量学 关联网络 文献研究 

分 类 号：R282.77[医药卫生—中药学]