附子不同炮制品灌胃Beagle犬的急性毒性研究  

Acute Toxicity Study on Intragastric Administration of Different Processed Radix Aconiti Lateralis Praeparata Products to Beagle Dogs

作　　者：宋玉琴[1] 张雪[2] 董艳红[2] 代良萍 彭成[2,3] 谢晓芳[2,3] 

机构地区：[1]成都中医药大学基础医学院,成都611137 [2]成都中医药大学药学院,成都611137 [3]中药资源系统研究与开发利用省部共建国家重点实验室培育基地,成都611137

出　　处：《世界科学技术-中医药现代化》2015年第7期1432-1437,共6页Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology

基　　金：科学技术部国家"重大新药创制"科技重大专项(2013ZX09201018):中药大品种参附注射液技术改造;负责人:郝莉;科学技术部国家973项目(2012CB723502):基于西部道地药材的创新药物研究;负责人:彭成;科学技术部国家"十二五"科技支撑计划项目(2011BAI13B05):西南区域附子;灯盏花等大宗中药材质量标准提高及其综合利用;负责人:彭成

摘　　要：目的:探讨附子不同炮制品灌胃Beagle犬的急性毒性。方法:取健康、合格Beagle犬16只,按体质量随机分为空白组、刨附片组、炮天雄组和黑顺片组。以4 g生药/kg灌胃给药,实验前及给药后1 h、24 h和第3、7、14天测定体质量、耗食量、肛温、心电图及血常规、血生化。结果:3个实验组Beagle犬在给药后均精神萎靡,血液电解质有显著性差异,其中黑顺片组最明显;刨附片组犬的红细胞、血糖和甘油三酯有显著性差异;炮天雄组犬的淋巴细胞和血糖有显著性差异,而黑顺片给药后犬的淋巴细胞显著降低。结论:3个炮制品毒性大小依次为黑顺片>刨附片>炮天雄。This article was aimed to study the acute toxicities on intragastric administration of differentRadix Aconiti Lateralis Praeparataprocessed products to Beagle dogs. A total of 16 healthy and qualified Beagle dogs were randomly divided into the blank group,Pao-Fu-Pian（PFP） group,Pao-Tian-Xiong（PTX） group andHei-Shun-Pian（HSP） group according to the body weight. The intragastric administration of 4 g crude herb per kg was given. Before medication, 1 h, 24 h, and 3, 7, 14 days after medication, the body weight, food consumption, rectal temperature, electrocardiogram, blood routine and blood biochemistry were measured. The results showed that after medication, all dogs in three experimental groups were depressed. And there were significant differences in the electrolytes of blood. Among them, the HSP group was the most obvious one. The red blood cells, blood sugar and triglycerides of dogs in the PFP group had significant difference. The lymphocytes and blood sugar had significant difference of dogs in the PTX group. However, after the medication of HSP, the lymphocytes of the dogs were decreased significantly. It was concluded that the toxicity of three processed products followed the order of HSP 〉 PFP 〉 PTX.

关 键 词：附子 炮制品 急性毒性 实验研究 

分 类 号：R285.5[医药卫生—中药学]