益气活血方治疗缺血性脑卒中的Meta分析  

Cerebral Ischemic Stroke Treatment: A Meta-analysis

作　　者：周瑜[1] 方锐[1] 王国佐[1] 葛金文[1] 

机构地区：[1]湖南中医药大学中西医结合学院,长沙410208

出　　处：《世界科学技术-中医药现代化》2015年第7期1537-1545,共9页Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology

基　　金：国家自然科学基金委面上项目(30572370):血清与血浆药理方法对脑泰方药物化学与药效学的对比研究;负责人:葛金文;国家自然科学基金委青年项目(81202794):特异性蛋白质相互作用网络在脑梗死发生中的作用及中药脑泰方干预机制研究;负责人:王国佐;湖南省教育厅研究生科研创新项目(CX2013B341):基于Rho/ROCK信号通路研究益气活血法对脑梗死大鼠神经保护的作用机理;负责人:周瑜

摘　　要：目的:系统评价益气活血方治疗缺血性脑卒中的疗效及安全性。方法:计算机检索国内外相关数据库,查找益气活血方药治疗缺血性脑卒中的随机对照试验相关文献,采用Rev Man 5.0软件进行Meta分析。结果:共纳入合格文献27篇,共2 908例患者,其中治疗组1 490例,对照组1 418例。Meta分析结果:益气活血方药或其联合西药常规治疗缺血性脑卒中临床疗效方面与单纯应用西药治疗比较,其差异均有统计学意义[OR=5.39,95%CI(4.03,7.22),P<0.000 01];益气活血方联合西药常规治疗缺血性脑卒中神经功能缺损方面与单独应用西药常规治疗比较,其差异也均有统计学意义[WMD=-2.99,95%CI(-3.26,-2.72),P<0.000 01];此外,益气活血方联合西药常规治疗缺血性脑卒中在改善日常生活能力方面亦优于单独应用西药常规治疗[WMD=9.65,95%CI(8.36,10.93),P<0.000 01]。其中2篇研究的不良反应表现轻微。结论:现有的相关数据表明,益气活血方或益气活血方联合西药常规治疗缺血性脑卒中较单纯西医治疗临床疗效更好,且能明显改善神经功能损伤,提高日常生活能力。由于本Meta分析纳入研究较少,证据强度有限,上述结论仍需更多高质量研究加以验证。This systematic review was aimed to evaluation the effectiveness and safety of supplementingqi and activating blood circulation prescriptions in the treatment of cerebral ischemic stroke. Dtabases both at home and abroad were electronically searched for randomized controlled trials （RCTs） on supplementingqi and activating blood circulation prescriptions in the treatment of cerebral ischemic stroke. And meta-analyses were performed using RevMan 5.0 software. The results showed that 27 studies were included, which contained 2 908 cases. There were 1 490 cases in the treatment group, and 1 418 cases in the control group. The results of meta-analyses indicated that supplementingqi and activating blood circulation prescriptions combined with routine treatment of modern medicine had significant differences in the effective rate for cerebral ischemic stroke compared with the single using of routine treatment of modern medicine with significant difference （OR = 5.39, 95%CI （4.03, 7.22）,P ＆lt; 0.000 01）. The treatment of supplementingqi and activating blood circulation prescriptions combined with routine treatment of modern medicine had better treatment effect on＆amp;nbsp;neurological function defects for cerebral ischemic stroke compared with the single using of routine treatment of modern medicine with significant difference （WMD = -2.99, 95%CI （-3.26, -2.72）,P ＆lt; 0.000 01）. In addition, the treatment of supplementingqi and activating blood circulation prescriptions combined with routine treatment of modern medicine had better treatment effect on improving the activity of daily living （WMD = 9.65, 95%CI （8.36, 10.93）,P ＆lt; 0.000 01）. Adverse reaction and event was mild in 2 included research reports. It was concluded that the treatment of supplementingqi and activating blood circulation prescription or it combined with routine treatment in modern medicine was quite effective in the treatment of cerebral ischemic stroke by the existed limited evidences. It can also improve the nerve

关 键 词：益气活血方 缺血性脑卒中 随机对照试验 META分析 

分 类 号：R932[医药卫生—生药学]