子宫上皮细胞稳定性FH检测在诊断宫颈癌及癌前病变中的临床意义  

The Clinical Significance of Uterine Epithelial Cells Stability FH Test in Cervical Cancer and Precancerous Lesions

作　　者：李姗[1] 宗丽菊 孟丽华[1] 杨子焱[1] 贾琳[1] 乔云波[1] 崔保霞[1] 张友忠[1] 孔北华[1] 

机构地区：[1]山东大学齐鲁医院,山东济南250012

出　　处：《中国肿瘤》2015年第10期881-883,共3页China Cancer

基　　金：山东省科技发展计划项目(2014GGH218029);山东大学齐鲁医院科研基金资助项目(2015QLMS48)

摘　　要：[目的]评价子宫上皮细胞稳定性FH检测技术在诊断宫颈癌及癌前病变中的临床意义。[方法]对经病理学诊断的宫颈上皮内瘤变（CIN）、宫颈癌、宫颈良性病变及宫颈正常的女性共540例,进行子宫上皮细胞稳定性FH检测和宫颈细胞学（TCT）检查,比较两种检测方法的敏感度及特异性。[结果]子宫上皮细胞稳定性FH检测诊断CIN2-3、宫颈癌的敏感度分别为76.3%（95%CI：70.3%-82.2%）、94.4%（95%CI：89.1%-99.7%）,与TCT检测的敏感度差异无统计学意义。子宫上皮细胞稳定性FH检测诊断宫颈病变的特异性为64.4%（95%CI：58.7%-70.2%）,低于TCT检测的特异性。[结论 ]子宫上皮细胞稳定性FH检测对诊断宫颈病变具有较高的敏感度,且具有快速、简便、经济的特点,适用于偏远贫困地区女性的宫颈癌筛查。[Purpose] To investigate the clinical significance of uterine epithelial cells stability FH test in cervical cancer and precancerous lesions. [Methods] A total of 540 women pathologically diagnosed with cervical intraepithelial neoplasia（CIN）,cervical cancer,cervical benign lesions and normal cervix were detected by uterine epithelial cells stability FH test and Thin-prep cytology test（TCT）. The sensitivity and specificity of Thin-prep cytology test（TCT） and uterine epithelial cells stability FH test for cervical lesions were compared. [Results] The sensitivity of uterine epithelial cells stability FH test in detecting CIN,cervical cancer were 76.3%（95% CI：70.3% -82.2%）,94.4%（95% CI：89.1% -99.7%）,respectively,which was no significant difference compared with TCT test. The specificity of uterine epithelial cells stability FH test in detecting cervical lesions was 64.4%（95%CI：58.7%-70.2%）,which was lower than that in TCT test. [Conclusion] Uterine epithelial cells stability FH test,characterized as is rapid,simple and economical,has a high sensitivity in detecting cervical lesions,and can be used for cervical cancer screening,especially for women in remote poverty-stricken areas.

关 键 词：子宫上皮细胞稳定性FH检测 宫颈癌 游离亚铁血红素 敏感度 特异性 

分 类 号：R737.33[医药卫生—肿瘤]