氧氟沙星明胶微球的制备工艺研究  

Study in preparation of ofloxaxcin gelatin microspheres

作　　者：张伟光 邸凯[1] 

机构地区：[1]齐齐哈尔大学化学与化学工程学院,黑龙江齐齐哈尔161006

出　　处：《天津医药》2015年第10期1140-1143,I0003,共5页Tianjin Medical Journal

摘　　要：目的研究制备氧氟沙星明胶微球的最佳工艺条件。方法以明胶为载体,液体石蜡为油相,Span80为乳化剂,戊二醛为交联剂,采用乳化交联法制备氧氟沙星明胶微球。采用紫外分光光度法测定微球中氧氟沙星的载药量和包封率。考察明胶质量分数、油水相体积比、明胶与氧氟沙星质量比、Span80体积分数对载药量、包封率的影响。以载药量、包封率的总和为评价指标,针对上述4个因素用L9(34)表正交试验设计法进行实验,获得最佳配方比例。结果氧氟沙星明胶微球分别在明胶质量分数20%、油水相体积比为3.5∶1、明胶与氧氟沙星质量比1∶1、Span80体积分数2.5%时,各自载药量、包封率的综合评价指标较高。正交设计证实上述条件下制备工艺最佳。结论本制备工艺稳定可行,氧氟沙星明胶微球的载药量和包封率可达到约80%。Objective To study the optimum condition of preparing ofloxaxcin gelatin microspheres. Methods Oflox-axcin gelatin microspheres were manufactured using the emulsion chemical-cross linking method and gelatin was employed as carrier, liquid paraffin as oil phase, Span80 as emulsifier, . The loading capability and entrapment efficiency of the ofloxax-cin gelatin microspheres were determined by UV Spectrophotometry. The effect of gelatin concentration, oil/water volume ra-tio, gelatin/ofloxaxcin mass ratio and volume fraction of span80 on drug loading capability and entrapment efficiency were in-vestigated. The optimum proportions of each component was obtained by L9 （34） orthogonal test, based on the above 4 factors, using sum of drug loading capability and entrapment efficiency as evaluation index. Results The optimum condition for manufacturing high quality ofloxaxcin gelatin microspheres used 20%of gelatin concentration,water/oil volume ratio at 3.5∶1, gelatin/ofloxaxcin mass ratio at 1∶1, the span 80 volume fraction of 2.5%. Conclusion Drug loading capability and entrap-ment efficiency of the ofloxaxcin gelatin microspheres reached 80%using this manufacture technology therefore the prepara-tion was stable and feasible.

关 键 词：氧氟沙星 聚明胶肽 微球体 工艺学 制药 药物载体 药物评价 

分 类 号：R944[医药卫生—药剂学]