IL-23/IL-17轴在强直性脊柱炎发病中的作用及治疗意义研究进展  

Roles of IL-23/IL-17 axis in pathogenesis and treatment of ankylosing spondylitis

作　　者：陈超[1] 李建军[2] 

机构地区：[1]天津医院脊柱外科,天津300233 [2]中国康复研究中心北京博爱医院

出　　处：《天津医药》2015年第10期1213-1216,共4页Tianjin Medical Journal

基　　金：北京市博士后A类经费资助课题(2011ZZ-02);中国康复研究中心科研基金面上课题(2011-24)

摘　　要：强直性脊柱炎(AS)发病机制至今不明,治疗效果不佳。白细胞介素(IL)-23/IL-17轴是近几年受到高度重视的重要免疫通路。本文对IL-23/IL-17轴在AS发病遗传学和免疫学中的作用进行论述,并介绍了抗IL-23和抗IL-17抗体用于治疗AS的新进展。IL-23/IL-17轴在AS发病和治疗中的重要作用提示其可能成为一个有效的新治疗靶点。The treatments for ankylosing spondylitis （AS） are still not effective, which partially due to its unclear patho-genesis. Interleukin （IL）-23/IL-17 axis is a significant immunologic pathway which has attracted much attention in the past few years. This article reviewed the role of IL-23/IL-17 axis in genetic and immunological pathogenesis of AS, and intro-duced the recent progresses in treatments of AS using anti-IL-23 or anti-IL-17 antibody. The important role of IL-23/IL-17 axis in the pathogenesis and treatment of AS indicates its potential use as a new therapeutic target.

关 键 词：脊柱炎 强直性 白细胞介素23 白细胞介素17 免疫疗法 综述 IL-23/IL-17轴 

分 类 号：R593.23[医药卫生—内科学]