琥珀酸美托洛尔缓释片对慢性心力衰竭患者心功能、6分钟步行试验距离及血浆脑钠肽水平的影响研究  

Impact of Metoprolol Succinate Sustained- release Tablets on Cardiac Function,6-minute Walking Distance and Plasma BNP Level of Chronic Heart Failure Patients

作　　者：张建兴[1] 

机构地区：[1]南方医科大学第五附属医院心内科,广东省广州市510900

出　　处：《实用心脑肺血管病杂志》2015年第8期25-27,共3页Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease

基　　金：广州市医药卫生科技项目(20151A011110)

摘　　要：目的探讨琥珀酸美托洛尔缓释片对慢性心力衰竭(CHF)患者心功能、6分钟步行试验(6MWT)距离及血浆脑钠肽(BNP)水平的影响。方法选取2012年3月—2014年8月南方医科大学第五附属医院心内科收治的CHF患者98例,按随机数字表法分为试验组和对照组,各49例。对照组患者给予利尿剂、血管扩张剂、强心类药物等常规药物治疗;试验组患者在常规药物治疗基础上加服琥珀酸美托洛尔缓释片。治疗3个月后评价临床疗效,比较两组患者治疗前和治疗3个月后心功能指标〔左心室舒张末期内径(LVEDD)、左心室收缩末期内径(LVESD)及左心室射血分数(LVEF)〕、6MWT距离及血浆BNP水平,并观察治疗期间不良反应发生情况。结果治疗前两组患者LVEDD、LVESD及LVEF比较,差异无统计学意义(P>0.05);治疗后试验组患者LVEDD和LVESD小于对照组,LVEF高于对照组(P<0.05)。治疗前两组患者6MWT距离及血浆BNP水平比较,差异无统计学意义(P>0.05);治疗后试验组患者6MWT距离长于对照组,血浆BNP水平低于对照组(P<0.05)。试验组患者临床疗效优于对照组(u=4.021,P<0.05)。治疗期间试验组患者6例出现轻微不良反应。结论琥珀酸美托洛尔缓释片能有效提高CHF患者临床疗效,改善患者心功能、增加6MWT距离、降低血浆BNP水平,且安全性较高。Objective To investigate the impact of metoprolol succinate sustained - release tablets on cardiac function,6-minute walking distance and plasma BNP level of chronic heart failure patients. Methods From March 2012 to August 2014,a total of 98 chronic heart failure patients were selected in the Department of Cardiology,the Fifth Affiliated Hospital of Southern Medical University,and they were divided into control group and test group according to random number table,each of 49 cases. Patients of control group received routine drug treatment,including diuretic,vasoliator,cardiotonic drugs and so on,while patients of test group received extra metoprolol succinate sustained-release tablets based on routine drug treatment. After 3 months of treatment,clinical effect was evaluated;cardiac function index（ including LVEDD,LVESD and LVEF）,6-minute walking distance and plasma BNP level before and after 3 months of treatment were compared between the two groups,and incidence of adverse reactions during treatment was observed. Results No statistically significant differences of LVEDD,LVESD or LVEF was found between the two groups before treatment （ P〉0. 05 ）;after treatment, LVEDD and LVESD of test group were statistically significantly shorter than those control group,while LVEF of test group was statistically significantly higher than that of control group（P〈0. 05）. No statistically significant differences of 6-minute walking distance or plasma BNP level was found between the two groups before treatment （ P〈0. 05 ）;after treatment,6 - minute walking distance of test group was statistically significantly longer than that of control group,while plasma BNP level of test group was statistically significantly lower than that of control group（P〈0. 05）. The clinical effect of test group was statistically significantly better than that of control group（u=4. 021,P〈0. 05）. During treatment,6 cases of test group occurred mild adverse reactions. Conclusion Metoprolol succinate sustained-release tablet

关 键 词：心力衰竭 美托洛尔 利钠肽 脑 6分钟步行试验 

分 类 号：R541.6[医药卫生—心血管疾病]