氧气雾化吸入与超声雾化吸入沙丁胺醇联合布地奈德治疗小儿肺炎的临床疗效对比  

Comparative Study for Clinical Effect on Infantile Pneumonia between Oxygen Atomizing Inhalation and Ultrasound Atomizing Inhalation of Salbutamol Combined with Budesonide

作　　者：黄小英[1] 林素惠[1] 陈国华[1] 

机构地区：[1]广东省惠州市第一人民医院儿科,516003

出　　处：《实用心脑肺血管病杂志》2015年第8期57-59,共3页Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease

摘　　要：目的比较氧气雾化吸入与超声雾化吸入沙丁胺醇联合布地奈德治疗小儿肺炎的临床疗效。方法选取2013年1月—2014年1月惠州市第一人民医院儿科收治的肺炎患儿80例,随机分为研究组和对照组,每组40例。两组患儿均给予常规治疗,对照组患儿采用沙丁胺醇联合布地奈德超声雾化吸入治疗,研究组患儿采用沙丁胺醇联合布地奈德氧气雾化吸入治疗;两组患儿均治疗7 d。比较两组患儿临床疗效、临床症状(咳嗽、肺部啰音、发热)消失时间、住院时间及不良反应发生情况,治疗前后血清肿瘤坏死因子α(TNF-α)、干扰素γ(IFN-γ)和白介素4(IL-4)水平。结果研究组患儿临床疗效优于对照组(u=5.380,P<0.05)。研究组患儿咳嗽消失时间、肺部啰音消失时间、发热消失时间及住院时间均短于对照组(P<0.05)。治疗前两组患儿血清TNF-α、IFN-γ、IL-4水平比较,差异无统计学意义(P>0.05);治疗后研究组患儿血清TNF-α、IFN-γ、IL-4水平均低于对照组(P<0.05)。研究组患儿不良反应发生率为7.5%,对照组患儿不良反应发生率为2.5%,差异无统计学意义(P>0.05)。结论氧气雾化吸入沙丁胺醇联合布地奈德治疗小儿肺炎的临床疗效优于超声雾化吸入,有利于缩短患儿临床症状消失时间及住院时间,且无严重不良反应。Objective To compare the clinical effect on infantile pneumonia between oxygen atomizing inhalation and ultrasound atomizing inhalation of salbutamol combined with budesonide. Methods A total of 80 children with pneumonia were selected in the First People′s Hospital of Huizhou from January 2013 to January 2014 , and they were randomly divided into control group and study group, each of 40 cases. Based on conventional treatment, children of control group were given ultrasound atomizing inhalation of salbutamol combined with budesonide, while children of study group were given oxygen atomizing inhalation of salbutamol combined with budesonide,both groups treated for 7 days. Clinical effect,clinical symptoms （ cough,lung rale,fever） disappeared time,hospital stays,incidence of adverse reactions,serum levels of TNF-α,IFN-γand IL-4 before and after treatment were compared between the two groups. Results The clinical effect of study group was statistically significantly better than that of control group （ u = 5. 380, P〈 0. 05 ）. Cough disappeared time, lung rale disappeared time,fever disappeared time and hospital stays of study group were statistically significantly shorter than those of control group（P〈0. 05）. No statistically significant differences of serum levels of TNF -α,IFN -γ or IL-4 was found between the two groups before treatment（P〉0. 05）,while serum levels of TNF-α,IFN-γ and IL-4 of study group were statistically significantly lower than those of control group after treatment（P〈0. 05）. The incidence of adverse reactions of study group was 7. 5%, that of control group was 2. 5%, the difference was not statistically significantly different （ P〉0. 05 ）. Conclusion Oxygen atomizing inhalation of salbutamol combined with budesonide has better clinical effect than ultrasound atomizing inhalation in treating infantile pneumonia,is helpful to shorten the clinical symptoms disappeared time and hospital stays,is without severe adverse reactions.

关 键 词：肺炎 儿童 沙丁胺醇 布地奈德 投药 吸入 疗效比较研究 

分 类 号：R563.1[医药卫生—呼吸系统]