肺炎衣原体感染对急性脑梗死患者病变过程的影响研究  

Effect of Chlamydia pneumoniae infection on the process of pathological changes of patients with acute cerebral infarction

作　　者：肖文[1] 王瑜琴 贾秀丽[1] 薛海龙[1] 王军文[1] 

机构地区：[1]解放军第三医院神经内科,陕西宝鸡721004 [2]兰州军区西安翠华路第三干休所,陕西西安710061

出　　处：《中华医院感染学杂志》2015年第20期4633-4635,共3页Chinese Journal of Nosocomiology

基　　金：陕西省科技厅基金资助项目(2004C237)

摘　　要：目的研究肺炎衣原体感染对急性脑梗死患者病变过程的影响,探讨肺炎衣原体感染与老年急性脑梗死的相关性。方法选择2014年1月-2015年1月在医院住院并确诊为急性脑梗死的患者95例,选取同期医院进行体检的健康人群95名为对照组,比较两组受试者的感染情况及感染与未感染者的血脂、C-反应蛋白、同型半胱氨酸、纤维蛋白原水平。结果观察组患者的慢性感染率、IgA抗体阳性率、IgG抗体阳性率,分别为74.74%、83.16%、86.32%,均明显高于对照组的46.32%、42.11%、62.11%,差异有统计学意义(P<0.05);两组急性感染率、IgM抗体阳性率比较差异无统计学意义;按照患者感染情况,将观察组患者分为感染与未感染,感染患者的CRP、HCY、FIB水平均明显高于未感染患者,差异有统计学意义(P<0.05);感染患者的LDL、TC、TG水平均明显高于未感染患者,HDL水平低于未感染患者,差异有统计学意义(P<0.05)。结论肺炎衣原体感染与急性脑梗死有关,可通过血脂代谢异常,提高CRP、HCY、FIB水平促进动脉硬化,导致急性脑梗死。OBJECTIVE To study the effect of Chlamydia pneumoniae infection on the process of pathological chan‐ges of patients with acute cerebral infarction ,so as to investigate the relationship between C .pneumoniae infection and acute cerebral infarction in the elderly .METHODS Totally 95 cases of patients who stayed in the hospital and diagnosed with acute cerebral infarction between Jan .2014 and Jan .2015 were selected as the observation group . Another 95 healthy cases who came to the hospital for physical examination at the same time were selected as the control group .Infection conditions were compared between the two groups and infection cases and blood lipid , CRP ,HCY ,FIB levels were compared between infected and uninfected patients .RESULTS The chronic infection rate and the positive rates of IgA and IgG antibodies were 74 .74% ,83 .16% and 86 .32% in the observation group ,significantly higher than 46 .32% ,42 .11% and 62 .11% in the control group （P〈0 .05） .The difference in acute infection and positive rate of IgM antibody between the two groups had no significance .According to the situation of patients with infections ,the observation group were divided into infected cases and uninfected cases . The CRP ,HCY ,FIB levels of infected patients were significantly higher than those of uninfected patients（P〈0 .05） .LDL ,TC ,and TG levels of infected patients were significantly higher than those of uninfected patients , while HDL level was significantly lower than that of uninfected patients（P〈0 .05） .CONCLUSION C .pneumoniae infection is associated with acute cerebral infarction and it can improve the level of CRP ,HCY ,FIB ,promoting atherosclerosis through blood lipid metabolic abnormalities and leading to acute cerebral infarction .

关 键 词：肺炎衣原体 感染 急性脑梗死 

分 类 号：R374[医药卫生—病原生物学]