两种联合用药方法治疗经磺脲类降糖药物治疗继发失效的2型糖尿病的研究  

Clinical comparative analysis of 25 diabetic patients with type 2 diabetes treated with different insulin

作　　者：冯茜[1] 

机构地区：[1]泗洪县人民医院药材科,宿迁223900

出　　处：《中国处方药》2015年第10期14-15,共2页Journal of China Prescription Drug

摘　　要：目的探讨甘精胰岛素或精蛋白锌重组赖脯胰岛素混和注射液分别联合二甲双胍治疗经磺脲类降糖药物治疗继发失效的2型糖尿病的临床疗效和安全性。方法 2011年3月~2012年11月期间收治的磺脲类降糖药物继发失效的2型糖尿病50例为研究对象,A组患者给予精蛋白锌重组赖脯胰岛素混和注射液（优泌乐25）联合二甲双胍进行治疗;B组患者给予甘精胰岛素联合二甲双胍进行治疗,治疗3个月后,比较两组患者的临床治疗效果。结果治疗完成后,两组患者的体重均有不同程度的增加,但是前后比较差异无统计学意义（P〉0.05）;精蛋白锌重组赖脯胰岛素混和注射液联合二甲双胍治疗组在早、中、晚饭后2 h PBG的控制上优于甘精胰岛素联合二甲双胍治疗组（P〈0.05）,而在FBG水平的控制稍逊甘精胰岛素联合二甲双胍治疗组,但未见明显统计学差异（P〉0.05）。经治疗,精蛋白锌重组赖脯胰岛素混和注射液联合二甲双胍治疗组的糖化血红蛋白低于甘精胰岛素联合二甲双胍治疗组,组间差异具有统计学意义（P〈0.05）。结论在磺脲类降糖药物继发失效的治疗中,优泌乐25联合二甲双胍治疗效果更好。Objective To observe the clinical efficacy of Gan insulin glargine or Humalog 25 respectively combined with metformin treatment in type 2 diabetes with secondary failure caused by the treatment of drugsulfonylurea antidiabetic drugs. Comparing the safety and effectiveness of the two groups of patients Methods From March 2011 to November 2012, 50 cases of type 2 diabetes patients with secondary failure caused by the treatment of drug sulfonylurea antidiabetic were selected as the objects for the study, 25 cases in each. Patients in group A were given protamine zinc recombinant human insulin lispro mixed injection（Humalog 25） in combination with metformin treatment; group B patients were given Gan insulin glargine combined with metformin treatment,and 3 months after treatment, compared two groups of patients with clinical treatment Results After treatment, the body weight of the two groups increased significantly, but the difference was not statistically significant（P〉0.05）; the 2 h PBG level in group A were superior better than that group B（P〈0.05）,but not the FBG level（P〉0.05）. Conclusion In the treatment of secondary failure of the drug, the effect of protamine zinc recombinant human insulin lispro mixed injection（Humalog 25） in combination with metformin treatment was better.

关 键 词：磺脲类降糖药物继发失效 甘精胰岛素 精蛋白锌重组赖脯胰岛素混和注射液 二甲双胍 

分 类 号：R587.1[医药卫生—内分泌]