铜催化的芳基酮及其衍生物氧化酰胺化合成α-酮酰胺的反应研究  

Copper-Catalyzed Oxidative Amidation of Aryl Ketone and Its Derivatives to Form α-Keto Amides

作　　者：龚久涵 朱正[1] 卢林[1] 郭生梅[1] 蔡琥[1] 

机构地区：[1]南昌大学化学学院,南昌330031

出　　处：《有机化学》2015年第9期1917-1922,共6页Chinese Journal of Organic Chemistry

基　　金：科技部973计划(No.2012CBA01204);国家自然科学基金(No.21302084)资助项目~~

摘　　要：研究了在水相体系下芳基酮类化合物与胺类化合物的氧化酰胺化合成α-酮酰胺的反应.室温条件下,以过氧叔丁醇(TBHP)为氧化剂,芳基酮与胺类化合物在铜盐与分子碘的协同作用下高效地得到了目标产物.同时研究了在以氧气为氧化剂的条件下,铜催化的酰基乙酸酯及其衍生物的C—C键断裂实现α-酮酰胺的合成.The oxidative amidation between aryl ketone and amine to form keto amide in water was studied. A variety of amides co-catalyzed by copper and iodine were efficiently synthesized using TBHP as an oxidant under room temperature. On the other hand, a copper-catalyzed C—C bond cleavage of β-keto ester and its derivatives to prepare α-keto amides under O2 atmosphere was also studied.

关 键 词：水 氧气 芳基酮 酰基乙酸酯 α-酮酰胺 

分 类 号：O623.626[理学—有机化学]