异硫氰酸酯的合成改进  

Improvement of the Synthesis of Isothiocyanates

作　　者：李正义[1] 石嵩[1] 庄跃[1] 郑崇谦 张金龙[1] 孙小强[1] 

机构地区：[1]常州大学石油化工学院江苏省绿色催化材料与技术重点实验室,常州213164

出　　处：《有机化学》2015年第9期1999-2003,共5页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(No.21002009);江苏省高校自然科学研究(Nos.12KJA150002,14KJA150002);江苏省科技(BY2014037-01);江苏省青蓝工程资助项目~~

摘　　要：以硫代氯甲酸苯酯和伯胺为原料,无需额外加碱条件下分别通过一步或两步反应实现异硫氰酸酯的合成.一步合成法对高活性胺底物比较有效,而两步合成法具有广泛的底物适用范围.该方法具有环境友好、原料易得、低毒和操作简便等许多优点,具有很好的工业应用前景.Isothiocyanates were prepared from the reactions of phenyl chlorothionoformate and various primary amines vis one-step or two-step process without additional base. The one-step process is good at highly active amines, while two-step approach is suitable for all kinds of amines. This method has many merits such as environment-friendly, easily available raw materials, low toxicity and convenient operation, which has a good application prospect in industry.

关 键 词：异硫氰酸酯 硫代氯甲酸苯酯 伯胺 合成 

分 类 号：TQ226.65[化学工程—有机化工]