安胃疡胶囊质量标准研究  

Quality Standard for Anweiyang Capsules

作　　者：毛丹[1,2] 毛秀红[2] 吴弢[1] 季申[2] 

机构地区：[1]上海中医药大学,上海201203 [2]上海市食品药品检验所

出　　处：《中国药师》2015年第10期1705-1707,共3页China Pharmacist

摘　　要：目的：研究修订安胃疡胶囊的质量标准。方法：采用薄层色谱法对制剂中甘草进行定性测定;采用高效液相色谱法对甘草查尔酮甲进行定量测定,采用C18柱,流动相为乙腈-0.1%磷酸溶液（40∶60）,检测波长为376 nm。结果：薄层色谱斑点清晰,分离度好,阴性无干扰。含量测定中甘草查尔酮甲在25.563-1 533.798 ng的范围内线性关系良好（r=0.999 9）,加样回收率为99.8%（n=9）。结论：该法简便、准确,进一步完善了安胃疡胶囊的质量标准,可作为质量控制标准。Objective：To improve the quality standard for Anweiyang capsules. Methods： TLC was used to identify Glycyrrhiza inflata Bat. Licochalcone A was determined by RP-HPLC. Using a C18 Column, the mobile phase consisted of acetonitrile-0. 1% phos-phoric acid（40：60）, and the detection wavelength was at 376 nm. Results：The herb could be identified by TLC. For licochalcone A, the linear range was from 25. 563 to 1 533. 798 ng, and the average recovery was 99. 8%（n=9）. Conclusion：The method is simple and accurate, which can be used to improve and control the quality of Anweiyang capsules.

关 键 词：安胃疡胶囊 质量标准 甘草查尔酮甲 薄层色谱法 高效液相色谱法 

分 类 号：TQ460.72[医药卫生—药物分析学]