奥美拉唑联合谷氨酰胺预防应激性溃疡效果观察  

Effect of Omeprazole Combined with Glutamine in the Prevention of Stress Ulcer

作　　者：赵展[1] 李卜武 叶欢乐 翟华伟[1] 

机构地区：[1]瑞安市人民医院,浙江瑞安325200

出　　处：《中国药师》2015年第10期1750-1752,共3页China Pharmacist

摘　　要：目的:观察奥美拉唑联合谷氨酰胺预防应激性溃疡的效果。方法:我院ICU收治的重症患者106例根据入院时间先后将患者分成观察组和对照组各53例,对照组患者予谷氨酰胺治疗,观察组患者予奥美拉唑钠联合谷氨酰胺治疗,比较两组患者治疗后胃液p H变化情况、不良反应发生情况和应激性溃疡发病例数。结果:治疗4 d后,观察组患者胃液p H明显高于观察组患者(P<0.05),治疗7 d后两组间差异更大(P<0.05)。观察组患者治疗后出现的上消化道症状明显少于对照组患者(P<0.05)。观察组应激性溃疡发病率为5.66%,明显低于对照组的24.53%(P<0.05)。两组药品不良反应发生率比较,差异无统计学意义(P>0.05)。结论:奥美拉唑联合谷氨酰胺预防应激性溃疡临床疗效好,有效抑制胃酸分泌,快速升高胃液p H,患者应激性溃疡发病率低,不良反应少,值得临床推广。Objective ： To study the effect of omeprazole combined with glutamine in the prevention of stress ulcer. Methods： Totally 106 cases of severe patients admitted in ICU of our hospital were divided into the observation group and the control group with 53 ones in each according to the admission order. The patients in the control group were treated with glutamine, and those in the observation group were treated with sodium omeprazole combined with glutamine. The pH change in gastric juice, adverse reactions and inci- dence of stress ulcer after the treatment were observed and compared between the two groups. Results： After the 4-day treatment, the pH value of gastric juice in the observation group was significantly higher than that in the control group （ P 〈 0.05 ）, and after the 7- day treatment, the difference was more notable. After the treatment, the symptoms of upper digestive tract in the observation group were fewer than those in the control group （P 〈 0.05）. After the treatment, the observation group had three stress ulcer patients with the incidence rate of 5.66%, while that in the control group was higher （24.53%）, and the difference was statistically significant （P 〈 0.05）. There was no statistically significant difference in the adverse reactions between the two groups （ P 〉 0.05 ）. Conclusion： Omeprazole combined with glutamine in the prevention of ulcers stress shows promising clinical efficacy, which can effectively inhibit gastric acid secretion and rapidly increase pH value of gastric juice with low incidence of adverse reactions, mild symptoms and high security, and is worthy of wide use in clinics.

关 键 词：奥美拉唑 谷氨酰胺 应激性溃疡 疗效 

分 类 号：R975.2[医药卫生—药品]