新生儿高胆红素血症动物模型研究进展  

Research advances in animal models of neonatal hyperbilirubinemia

作　　者：杨李[1] 吴德[1] 唐久来[1] 

机构地区：[1]安徽医科大学第一附属医院小儿神经康复中心,合肥230032

出　　处：《中国比较医学杂志》2015年第9期78-80,共3页Chinese Journal of Comparative Medicine

基　　金：国家自然科学基项目(编号:81270665);科技部项目(编号:2014BAL03B00)

摘　　要：目前多种方法可建立新生儿高胆红素动物模型,如通过腹腔或静脉注射胆红素方法、利用基因缺陷动物模型、利用注射化学药物特殊的作用,以及延髓直接注射胆红素的方法等,为更好的利用动物模型进行高胆红素血症及所导致的核黄疸、听觉障碍等的病因、发病机制及治疗的研究,本文对新生儿高胆红素血症各类动物模型构建方法、应用和优缺点进行综述,以期为新生儿高胆红素血症模型的研究提供参考。There are many ways to establish animal models of neonatal hyperbilirubinemia,such as intraperitoneal or intravenous injection, genetic defect animal models, the use of chemical drugs, and injection of bilirubin into cerebellomedullary cistern, and so on. In order to study the etiology, pathogenesis, and therapy of neonatal hyperbilirubinemia through animal models,we review the literature on rodent and primate models of neonatal hyperbilirubinemia,including establishment of models and their applications,in order to provide reference for the research of neonatal hyperbilirubinemia.

关 键 词：新生儿高胆红素血症 模型 动物 

分 类 号：R33[医药卫生—人体生理学]