氯普鲁卡因、利多卡因预防丙泊酚静脉注射痛的效果比较  

Comparison of chloroprocaine with lidocaine in preventing propofol injecting pain

作　　者：傅润乔[1] 彭晓风[1] 任海强[1] 薛绵荣[1] 

机构地区：[1]北京市垂杨柳医院麻醉科,北京100022

出　　处：《空军医学杂志》2015年第3期165-167,共3页Medical Journal of Air Force

基　　金：北京市朝阳区科技计划基金(SF-0803)

摘　　要：目的比较氯普鲁卡因与利多卡因预防丙泊酚静脉注射痛的效果。方法 165例接受无痛人工流产早孕患者,随机分成盐酸氯普鲁卡因组（CP组,n=55）、盐酸利多卡因组（Li组,n=55）和生理盐水组（对照组,n=55）。分别注射2%CP 4 ml、2%Li 4 ml和生理盐水4 ml,30 s后注射丙泊酚2 mg/kg,边注射边询问患者注射部位及胳膊是否疼痛,直至患者入睡。术中麻醉深度不够追加丙泊酚0.5~1.0 mg/kg。结果无注射痛CP组达92.7%,Li组60.0%,对照组43.6%（P〈0.01）,且有痛的疼痛程度CP组比Li组轻,比对照组更轻。丙泊酚用量,CP组和Li组明显低于对照组（P〈0.01）。麻醉苏醒CP组和Li组比对照组快（P〈0.05）。结论氯普鲁卡因静脉预先注射对预防丙泊酚静脉注射痛效果较利多卡因好,二者也均可协同和增强丙泊酚静脉麻醉（中枢抑制）效果,且减少其用量。Objective To evaluate effects of chloroprocaine and lidocaine to prevent propofol injecting pain.Methods One hundred and sixty-five adult patients undergoing abortion were randomly divided into chloroprocaine（CP,n=55）,lidocaine（Li,n=55） and normal saline（control group,n=55） groups.A dose of 4 ml was venous injected at30 s before 2 mg/kg propofol anesthesia given by 2%CP,2%Li or control group.0.5~1 mg/kg was added when the depth of anesthesia was not enough.Results The incidences of painlessness of propofol injection were higher（P〈0.01）in group CP,accounting for 92.7%,60.0%and 43.6%in group CP,Li and control respectively,and injecting pain grade was lower in group CP than Li and control.It was lesser significant（P〈0.01） in group CP and Li than control group about propofol requirements and quicker significantly（P〈0.05） in group CP and Li in waking up from anesthesia.Conclusions Chloroprocaine is better than lidocaine in preventing pain caused by propofol venous injection,and can synergy and strengthen propofol anesthesia,reducing propofol requirements in therapeutic abortion.

关 键 词：氯普鲁卡因 利多卡因 丙泊酚 注射痛 人工流产 

分 类 号：R614.2[医药卫生—麻醉学]