植物源血管紧张素转换酶抑制剂的研究进展  

Review on Angiotensin Converting Enzyme Inhibitors Derived from Plants

作　　者：蒋丹[1] 赵楠楠[2] 赵英[3] 张佳蓉[1] 

机构地区：[1]北京联合大学生物化学工程学院,北京100023 [2]北京医院麻醉科,北京100730 [3]北京联合大学师范学院,北京100011

出　　处：《安徽农业科学》2015年第29期23-26,共4页Journal of Anhui Agricultural Sciences

基　　金：北京高等学校青年英才计划项目(YETP1747)

摘　　要：血管紧张素转换酶抑制剂(Angiotensin converting enzyme inhibitors,ACEI)通过肾素-血管紧张素系统(RAS)和激肽释放酶-肽酶系统(KKS),抑制血管紧张素II的生成,减少缓激肽的降解,从而达到降血压的目的;植物来源的天然化合物具有来源广泛、结构多样、特异性高、毒性低等特点,因而从植物中筛选安全有效的ACEI成为研究热点。在此综述了血管紧张素转换酶(ACE)的活性测定方法以及植物来源的不同结构类型的ACEI研究进展。Angiotensin converting enzyme inhibitors （ACEI） inhibit the formation of angiotensin II, reduce the degradation of bradykinin by the renin-angiotensin system （RAS） and kallikrein-peptide enzyme system （ KKS）, so as to achieve the purpose of lowering blood pressure. Plant- derived natural products have a lot of advantages, such as a wide range of sources, structural diversity, highly specificity and low toxicity. Therefore, screening of safe and effective ACEI derived from plant become a hot topic. This paper reviewed both the methods of determination of Angiotensin converting enzyme inhibiting activity and the Angiotensin converting enzyme inhibitors derived from plants based on the chemical structure.

关 键 词：ACE活性测定 植物源化合物 

分 类 号：R282.71[医药卫生—中药学]