锰的神经毒作用及其易感性生物标志物的选择  

Manganese neurotoxic effect and its susceptibility biomarkers of choice

作　　者：邵华[1] 

机构地区：[1]山东省职业卫生与职业病防治研究院,济南250062

出　　处：《中华预防医学杂志》2015年第10期856-859,共4页Chinese Journal of Preventive Medicine

摘　　要：长期职业接触锰，会引起进行性的、不可逆的神经系统病变。锰主要侵害基底神经节，选择性损伤多巴胺能神经元，其机制可能与干扰中枢神经的能量代谢，改变神经递质，激活氧化系统导致神经细胞退行性变性等有关；遗传因素也可能对锰所致神经毒性作用的发生起重要作用。研究锰神经毒性的接触性生物标志物、效应性生物标志物及基因易感性生物标志物等早期易感性生物标志物将有助于防治锰的神经毒作用。Long-term occupational exposure to manganese might cause manganese poisoning, which would had adverse effects on nervous system of workers. The basal nucleus was damaged and dopaminergic neuron was injuried by manganese. The mechanism could be related with interfering the energy metabolism of central nerve, changing neurotransmitters, activating oxidation system and so on. Genetic factors may also plays a significant role in the neurotoxicity caused by manganese. Study the effects of manganese exposure biomarker, the neurotoxicity of biomarkers and the genetic susceptibility to early and susceptibility biomarkers will contribute to the prevention and control of manganese neurotoxicity.

关 键 词：锰 锰中毒 神经毒性 生物标志物 

分 类 号：R135.1[医药卫生—劳动卫生]