3种中药复方对药物所致肝内胆汁淤积大鼠胆汁的影响  

Effects of 3 Chinese Formulas on Bile of Drug-Induced Cholestasic Rats

作　　者：陈菲[1,2] 方步武[2] 吴咸中[3] 

机构地区：[1]山东省聊城市人民医院药学部,山东聊城252000 [2]天津医科大学药理学教研室,天津300070 [3]天津市中西医结合急腹症研究所,天津300110

出　　处：《中国药业》2015年第20期14-16,共3页China Pharmaceuticals

基　　金：天津市科技攻关计划重大科技项目;项目编号:05YFGDSF02600

摘　　要：目的观察柴郁汤、芍甘汤和痛泻要方在α-异硫氰酸萘酯(ANIT)造成的大鼠肝内胆汁淤积模型上的利胆作用。方法将健康Wistar大鼠96只分为12组,即正常对照组,胆汁淤积模型组(简称模型组),柴郁汤低、中、高剂量组,芍甘汤低、中、高剂量组,痛泻要方低、中、高剂量组和熊去氧胆酸组,各8只。第1天对大鼠进行胆管插管;第2天早上正常对照组灌胃食用豆油,其余组灌胃4%ANIT;第4天早上各组均收集1 h胆汁,然后除正常对照组灌胃蒸馏水外,其余各组灌胃相应药物,晚上再灌胃1次,灌胃1 h后收集1 h胆汁;第5天早晚各灌胃1次,晚上灌胃1 h后收集1 h胆汁。结果与给药前比较,3种中药复方给药后第2天胆汁均明显增多(P<0.05)。结论柴郁汤、芍甘汤和痛泻要方对药物所致大鼠胆汁淤积皆有利胆作用。Objective To observe the influence of Chaiyu Decoction, Shaogan Decoction and Tongxie prescription on ANIT- induced cholestasic rats. Methods 96 healthy Wistar rats were divided into 12 groups,namely normal control group,model group, Chaiyu Decoc- tion groups of low, middle and high dose, Shaogan Decoction groups of low, middle and high dose, and Ursodeoxycholic acid tablet group. On day 1, rats were treated with bile duct intubation. On day 2,rats of normal control group were administered bean oil, and oth- er groups were treated with 4% ANIT. On day 4,each group was administered corresponding drug after being colleceted bile for 1 hour in the morning, and was treated accordingly again at night, then collected bile for 1 hour. On day 5, treatment was same as day 4 ex- cept rats were not collected bile in the morning. Results After treated with three Chinese traditional prescriptions bile of rats on day 2 was remarkably increased compared with group of non- treatment. Conclusion 3 traditional Chinese prescriptions Chaiyu Decoction, Shaogan Decoction,Tongxie prescription have cholagogic actions on ANIT-induced cholestasic rats.

关 键 词：α-异硫氰酸萘酯 柴郁汤 芍甘汤 痛泻要方 胆汁淤积 

分 类 号：R285.5[医药卫生—中药学] R289.5[医药卫生—中医学]