斑蝥酸钠维生素B_6联合替吉奥治疗Ⅳ期胰腺癌27例  

Disodium Cantharidinate and Vitamin B_6 Combined with Tegafur,Gimeracil and Oteracil Potassium for Treating Stage Ⅳ Pancreatic Cancer in 27 Cases

作　　者：关丽云[1] 马静[2] 袁世发 曲金荣[1] 

机构地区：[1]河北省石家庄市第三医院,河北石家庄050017 [2]河北医科大学第四医院,河北石家庄050011 [3]河北武警总队医院,河北石家庄050038

出　　处：《中国药业》2015年第20期124-125,共2页China Pharmaceuticals

摘　　要：目的观察斑蝥酸钠维生素B6注射液联合替吉奥胶囊治疗晚期胰腺癌的临床疗效。方法将54例晚期胰腺癌患者按随机数字表法分为治疗组和对照组,各27例。对照组患者采用替吉奥胶囊治疗,治疗组患者在此基础上加用斑螫酸钠维生素B6注射液治疗。治疗2个周期后,评价两组患者的近期疗效、临床效果及不良反应。结果治疗组总有效率和疾病控制率分别为11.11%和59.26%,对照组分别为7.41%和55.56%,组间比较,差异无统计学意义(P>0.05);治疗组不良反应发生率低于对照组(P<0.05),特别是白细胞减少、肝功能异常及恶心、呕吐不良反应发生率;治疗组卡氏生活质量(KPS)评分总有效率为81.48%,明显高于对照组的59.26%(P<0.05)。结论斑蝥酸钠维生素B6注射液能减轻替吉奥化疗毒副作用,提高生活质量和疗效,值得临床推广。Objective To observe the clinical effect of Disodium Cantharidinate and Vitamin B6 combined with tegafur, gimeracil and oteracil potassium for treating advanced pancreatic cancer. Methods Totally 54 patients with advanced pancreatic cancer were divided into the treatment group and the control group according to the random number method,27 cases in each group. The control group was given and tegafur,gimeracil oteracil potassium,while the treatment group was given Disodium Cantharidinate and Vitamin B6. The short- term effect,clinical effect and adverse reactions were evaluated after 2 courses. Results The total effective rate and the disease control rate in the treatment group was 11.11% ,59.26% respectively,and 7.41% ,55.56% in the control group respectively,the difference had no statistical significance（P 〉 0.05）;the adverse reavtion rate of leukopenia,abnormal liver function,nausea and vomiting in the treatment group was significantly lower than those in the control group （P 〈 0. 05）;the total effective rate of KPS score was 81.48%, which was significantly higher than 59. 26% in the control group（P 〈 0. 05） . Conclusion Disodium Cantharidinate and Vitamin B6 can reduce the toxic and side effect caused by tegafur, gimeracil and oteracil potassium, improve the quality of life, and is worth of clinical promotion.

关 键 词：斑蝥酸钠维生素B6注射液 替吉奥 胰腺癌 

分 类 号：R285.6[医药卫生—中药学] R286[医药卫生—中医学]