广州地区15岁及以上人群脂蛋白代谢紊乱流行情况及影响因素分析  

Epidemiological features and risk factors of lipoprotein metabolic disorder among residents aged 15 and older in Guangzhou

作　　者：饶珈铭 董晓梅[1] 叶云凤 王海清[1] 吴雪霁[2] 潘冰莹[2] 陈雄飞[2] 刘华章[2] 

机构地区：[1]暨南大学医学院,广东广州510632 [2]广州市疾病预防控制中心

出　　处：《华南预防医学》2015年第5期412-418,共7页South China Journal of Preventive Medicine

基　　金：广东省医学科学技术研究基金项目(A2013538)

摘　　要：目的了解广州地区15岁及以上居民脂蛋白代谢紊乱的流行特征及影响因素，为心脑血管疾病的早期预防及干预提供科学依据。方法运用多阶段整群随机抽样方法，抽取广州市9 600户家庭，对抽取户的15岁及以上居民进行问卷调查和体格检查，问卷内容包括调查对象家庭的一般情况、日常生活情况、脂蛋白代谢紊乱等慢性病患病情况，体格检查项目包括身高、体重、腰围、臀围及血压等。分别采用单因素和多因素logistic回归分析方法对脂蛋白代谢紊乱患病的影响因素进行分析。结果共调查15岁及以上居民23 994人，男女性别比为1∶1.03，其中年龄以35~44岁（20.3%）、学历以初中、高中/中专（54.2%）、职业以未就业（21.7%）为主。居民自报的脂蛋白代谢紊乱患病率为1.47%（352/23 994）。多因素logistic回归分析结果显示：年龄为55～65岁（OR=1.34）、高中/中专或大专及以上（OR=2.37、3.17）、离退休人群（OR=2.65）、新诊断或已诊断高血压（OR=1.54、5.26）、自报糖尿病（OR=2.33）、BMI异常（OR=2.78~10.33）是居民脂蛋白代谢紊乱的独立危险因素，而年龄为25~34、35~44（OR=0.13、0.46）、每日水果摄入量≥200 g（OR=0.77） 是居民脂蛋白代谢紊乱的保护因素（P〈0.05或P〈0.01）。结论广州地区成年人脂蛋白代谢紊乱自报的总体患病率较低，建议加强各社区高危人群筛查、提高人群对相关疾病的认知。合理的饮食、控制体重和防治高血压和糖尿病是预防减少脂蛋白代谢紊乱的有效措施。ObjectiveTo investigate prevalence of selfreported lipoprotein metabolic disorder and related risk factors among residents aged ≥15 years old in Guangzhou so as to provide a scientific basis for early prevention and intervention of cardiovascular and cerebrovascular diseases.MethodsUsing multistage cluster random sampling method, residents aged 15 years and older were selected from 9 600 households in Guangzhou for questionnaire survey and physical examination. Contents of the questionnaire included the general information, daily life, lipoprotein metabolic disorder, and other common chronic diseases. Items of physical examination included height, weight, waist, hip circumference, and blood pressure. Univariate and multivariate logistic regressions were used to analyze the risk factors of the diseases among different groups.ResultsA total of 23 994 residents aged 15 years and older were investigated. The male to female ratio was 1∶1.03. They were concentrated in the group aged 35-44 years （20.3%）; their education levels were mainly junior, senior or secondary school （54.2%） and the occupation was mainly the unemployed（21.7%）. The total prevalence of selfreported lipoprotein metabolic disorder was 1.47% （352/23 994）. Multivariate logistic regression analysis showed that age 55-65 years （OR=1.34）, high school/technical secondary school and college or above （OR=2.37, 3.17）, retirees （OR=2.65）, newly or ever diagnosed hypertension （OR=1.54, 5.26）, diabetes mellitus （OR=2.33）, and abnormal BMI （OR=2.78-10.33） were independent risk factors for lipoprotein metabolic disorder, while age groups at 25-34, 35-44 years old （OR=0.13,0.46） and fruit intake ≥200 g/d （OR=0.77） were protective factors for lipoprotein metabolic disorder （P〈0.05 or P〈0.01）.ConclusionThe total prevalence of selfreported lipoprotein metabolic disorder was low in Guangzhou. Each community should strengthen the high risk population screening and improve the awareness of the disease. Reasonab

关 键 词：脂蛋白类 营养和代谢性疾病 因素分析 统计学 

分 类 号：R589.2[医药卫生—内分泌]