血脂与突发性聋发病及疗效的相关分析  

Correlations between the pathogenesis and prognosis of sudden sensorineural hearing loss and blood lipid

作　　者：陈成芳[1] 王明明[1] 樊兆民[1] 张道宫[1] 吕亚峰[1] 王洪亚[2] 王海波[1] 

机构地区：[1]山东大学附属省立医院山东省耳鼻喉医院耳鼻咽喉头颈外科,济南250021 [2]山东大学附属省立医院山东省耳鼻喉医院检验科,济南250021

出　　处：《中华耳鼻咽喉头颈外科杂志》2015年第10期793-798,共6页Chinese Journal of Otorhinolaryngology Head and Neck Surgery

基　　金：山东省优秀中青年科学家科研奖励基金（BS2012YY028）;山东省科技发展计划（2014GSF118109）

摘　　要：目的探讨突发性聋患者血脂指标与突聋的发病及疗效是否存在相关关系。方法对2013年12月至2015年2月共258例突发性聋患者的临床资料进行回顾性分析，观察不同听力损失程度（轻度、中度、重度和极重度）、听力曲线类型（低频下降型、高频下降型、平坦型和全聋型）及疗效（痊愈、显效、有效和无效）的突发性聋患者血浆中各项血脂指标[包括总胆固醇（total cholesterol，TC）、甘油三酯（tfiglycefide，TG）、高密度脂蛋白胆固醇（hishdensity lipoprotein cholesterol，HDL—C）、低密度脂蛋白胆固醇（low density lipoprotein cholesterol，LDL—C）和非高密度脂蛋白胆固醇（non-high density lipoprotein，Non—HDL—C）等]的分布特征，使用SPSS22．0统计软件进行方差分析、卡方检验及多元回归分析。结果轻度聋患者血浆TG浓度明显低于重度和极重度聋患者，差异具有统计学意义（P值分别为0．017和0．007）。四种听力曲线类型和血脂指标之间均无相关性（P值均〉0．05）。有效组和无效组Non-HDL-C明显高于痊愈组（P值分别为0．021和0．026），显效和无效组的TC明显高于痊愈组（P值分别为0．049和0．042），有效组的TG明显高于痊愈组（P=0．014）。结论TG与突发性聋的听力损失程度呈正相关，Non—HDL—C、TC和TG与突发性聋患者的疗效呈负相关，可为判断预后提供参考。Objective We aimed to determine whether blood lipid parameters were related to the severity and the prognosis of idiopathic sudden scnsorineural hearing loss（ISSNHL） patients. Methods A retrospective cohort study of 258 patients with ISSNHL from December 2013 to February 2015. The distribution characteristics of lipids [ total cholesterol （ TC ） , triglyceride （ TG ）, high density lipoprotein cholesterol（ HDL-C）, low density lipoprotein cholesterol（ LDL-C ）, Non-high-density lipoprotein cholesterol （Non-HDL-C）, et al] in different degree of deafness （mild, moderate, severe, and profound）, hearing curve types （low frequency, high frequency, full range frequency, and completely deafness type ） and prognosis of recovery（ complete, partial, slight, and no recovery） were analyzed by IBM SPSS 22.0 ANOVA analysis, chi square test and multiple regression analysis. Results TG level in mild hearing loss group was significantly lower than that in severe and profound hearing loss group （ P = 0. 017 and P = 0. 007 ）. There were no correlation between curve types and lipid indexes （ P 〉 0.05 ）. Non-HDL-C level was elevated in no recovery and slight recovery groups （ P = 0. 026 and 0. 021 ）. TC levels in partial recovery group and no recovery group were significantly higher than that in the complete recovery group （ P = 0. 049 and 0. 042 ）, TG was higher in slight recovery group （P = 0. 014）. Conclusions TG has significant correlation with the severity of hearing loss. There are negative correlations between hearing recovery and Non-HDL-C, TC and TG levels. Non-HDL-C, TC and TG might be a prognostic factor for treatment outcome in ISSNHL patients.

关 键 词：听觉丧失 突发性 胆固醇 甘油三酯类 胆固醇 HDL 胆固醇 LDL 治疗结果 

分 类 号：R764.437[医药卫生—耳鼻咽喉科]