PAF拮抗剂BN50739对大鼠急性肺损伤的作用研究  

Effect of PAF antagonist BN50739 on acute lung injury in rats

作　　者：黄宏[1] 周萍[1] 刘友生[2] 陈意生[2] 蒋建新[1] 

机构地区：[1]第三军医大学附属大坪医院野战外科研究所第四研究室,重庆400042 [2]第三军医大学附属西南医院病理研究所,重庆400038

出　　处：《第三军医大学学报》2002年第8期919-920,共2页Journal of Third Military Medical University

基　　金：国家自然科学基金资助项目 ( 39732 10 )

摘　　要：目的　观察PAF拮抗剂BN5 0 73 9在治疗烧伤内毒素血症所致的急性肺损伤中的作用 ,为临床治疗提供依据。方法　采用烧伤复合内毒素血症大鼠模型 ,于致伤前 5min腹腔注射BN5 0 73 9。动态观察肺病理改变、血气分析、支气管肺泡灌洗液(BALF)中蛋白含量及肺内TNF表达。结果　BN5 0 73 9可以明显减轻肺水肿 ,使BALF中蛋白含量明显低于生理盐水对照组 ,使伤后 1 5h和 6h血氧分压明显提高。BN5 0 73 9尚能部分抑制TNF表达。结论　BN5 0 73 9能部分改善烧伤复合内毒素血症所致的急性肺损伤。Objective To observe the therapeutic effect of BN50739, a platelet activating factor (PAF) antagonist on the acute lung injury induced by burn injury combined with endotoxemia. Methods Third degree thermal injury of 20% total body surface area (TBSA) rats were prepared, and intraperitoneal injection of endotoxin were given to induce animal model of acute lung injury. BN50739 at 20 mg/kg was injected into the abdominal cavity of rats in treatment group 5 min before the injury. Histological changes of the lung, blood gas analyses, protein contents in the bronchoalveolar lavage fluid (BALF) and expression of TNG in lung tissue were investigated before. Results BN50739 significantly attenuated the pulmonary edema, and decreased lung vascular permeability for protein, and resulted in the decrease of the protein contents in BALF improvement of respiration and increase of the blood PO 2. BN50739 partially inhibited the expression of TNF in rat lung. Conclusion BN50739 might partially improve the acute lung injury induced by burns injury combined with endotoxemia in rat.

关 键 词：烧伤 内毒素血症 急性肺损伤 血小板活化因子 BN50739 

分 类 号：R644[医药卫生—外科学] R563[医药卫生—临床医学]