清热解毒中药降糖作用及机制研究进展  

Research progress in hypoglycemic effect and mechanism of heat-clearing and detoxifying Chinese materia medica

作　　者：洪金妮[1] 杨金霞[1] 王学美[1] 

机构地区：[1]北京大学第一医院中西医结合研究室,北京100034

出　　处：《中草药》2015年第17期2656-2661,共6页Chinese Traditional and Herbal Drugs

基　　金：国家"973"计划(2009CB523003);北京科技计划(D131100004713004)

摘　　要：中医认为热毒蕴结是糖尿病发生发展的重要病理机制之一,在辨证论治的基础上,使用清热解毒法能有效治疗糖尿病。清热解毒中药能通过保护胰岛细胞,改善胰岛素抵抗,调节糖脂代谢、调节胰高血糖素样肽-1(GLP-1)、炎症因子和肠道菌群等降低血糖。将对清热解毒方药降糖作用及其机制进行探讨。Heat-toxin stagnation is regarded to be an important pathologic mechanism of diabetes mellitus（DM） in terms of traditional Chinese medicine. Treating DM with heat-clearing and detoxifying principle on the basis of syndrome differentiation proves to be effective. Heat-clearing and detoxifying Chinese materia medica can decrease blood sugar by protecting islet β-cell, improving insulin resistance, regulating glucose metabolism and lipid metabolism, regulating GLP-1, inflammatory cytokines, and intestinal microflora.

关 键 词：糖尿病 清热解毒 降糖 作用机制 热毒 

分 类 号：R285[医药卫生—中药学]