血清胱抑素C对急诊冠脉介入患者造影剂肾病的诊断价值  

Value of cystatin C in the diagnosis of contrast- induced nephropathy in acute myocardial infarction paitents treated with percutaneous coronary intervention

作　　者：雷大洲[1] 王津生[1] 王岩[1] 

机构地区：[1]新乡市中心医院心内二科,河南新乡453000

出　　处：《河南医学研究》2015年第11期17-18,共2页Henan Medical Research

摘　　要：目的探讨血清胱抑素C(Cys C)对急诊冠脉介入患者造影剂肾病的诊断价值。方法选择行急诊经皮冠状动脉介入治疗(PCI)的232例AMI患者为研究对象。所有患者分别于PCI前、PCI后24 h和48 h抽血检测Cys C、肌酐(Scr)等生化指标,比较血清Cys C与Scr值早期诊断造影剂肾病的特异性和敏感度。结果 PCI后24 h和48 h血清Cys C诊断CIN的发生率分别为9.91%和11.63%,差异有统计学意义(P<0.05)。血清Cys C法在PCI后24 h诊断CIN的灵敏度和特异度分别为96.43%和95.87%,造影后48 h为90.88%和94.93%。结论 Cys C较Scr能更为敏感地反映造影剂肾毒性的程度,有利于接受急诊PCI的AMI患者造影剂肾病的早期诊断。Objective To explore the value of cystatin C in the diagnosis of contrast - induced nephropathy in acute myocardial infarction paitents treated with percutaneous coronary intervention. Methods A total of 232 acute myocardial infarction patients from Central Hospital of Xinxiang treated with percutaneous coronary intervention （PCI） were selected. Serum Cys C, creatinine （Set） and other relevant clinical indexes were detected before PCI and 24, 48 hours after PCI. The specifieities and sensitivities were compared. Results The incidences of CIN diagnosed by serum Cys C at 24, 48 hours after PCI were 9. 91% , 11.63 %, and the difference was statistically significant （P 〈 0. 05 ）. The specificities and sensitivities were 96. 43%, 95.87% at 24 hours after PCI, and 90. 88% , 94.93% at 48 hours after PCI. Conclusion The level of serum Cys C could be a sensitive marker to diagnose CIN in early stage after PCI.

关 键 词：胱抑素C 造影剂肾病 急性心肌梗死 

分 类 号：R542.22[医药卫生—心血管疾病]