复方苦参止痒霜对变态反应性皮炎大鼠模型血清中白三烯B4及皮损部位炎性反应的影响  

Influence of Fufang Kusheng Zhiyang Ointment on serum LTB4 and inflammation of skin lesion part of allergic dermatitis rats

作　　者：何文凤[1] 屈双擎[1] 霍春波[1] 张云璧[1] 

机构地区：[1]北京中医药大学东直门医院皮肤科,北京100700

出　　处：《中华中医药杂志》2015年第10期3726-3728,共3页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：北京中医药大学青年教师专项课题(No.2012-QNJSZX017)~~

摘　　要：目的:建立大鼠变态反应性接触性皮炎(ACD)模型,探讨复方苦参止痒霜治疗变态反应性皮炎的作用机制及作用靶点。方法:采用二硝基氯苯(DNCB)诱发的ACD大鼠模型,观察复方苦参止痒霜对大鼠血清中白三烯B4(LTB4)、背部皮损中白三烯受体1(BLT1)、Caspase-14等多个指标的影响,并观察炎性反应局部的病理改变。结果:治疗组大鼠血清LTB4水平明显低于模型组(P<0.01),BLT1、Caspase-14表达水平与模型组组间无统计学差异。结论:复方苦参止痒霜能够抑制LTB4-BLT通路,进而减轻局部炎性反应,达到治疗变态反应性皮炎的目的。Objective：To explore the mechanism and action targets of Fufang Kushen Zhiyang Ointment on allergic contact dermatitis（ACD） based on the ACD rat models.Methods：ACD rat models were established by using dinitrochlorobenzene（DNCB）.The influence of Fufang Kushen Zhiyang Ointment in indexes as serum LTB4,BLT1 and Caspase-14 of skin lesion were observed,and the pathologic change of inflammatory focus was also observed.Results：The serum LTB4 level of rats in treatment group was significantly lower than that of model group（P〈0.01）,and the difference in expression of BLT1 and Caspase-14 between treatment group and model group was not significant.Conclusion：Fufang Kushen Zhiyang Ointment could inhibit the LTB4-BLT pathway and reduce the local inflammatory response,in order to achieve the goal of treating allergic dermatitis.

关 键 词：复方苦参止痒霜 变态反应性皮炎 白三烯B4 白三烯受体1 Caspase-14 

分 类 号：R285.5[医药卫生—中药学] R-332[医药卫生—中医学]