2009~2014年河北邢台市A型H3N2流感病原学监测分析  

Epidemiological surveillance over the influenza A/H3N2 virus in Xingtai City from 2009 to 2014

作　　者：董江华[1] 孙伟明[1] 闫英民 庞俊华[1] 苏铭[1] 陈风阳[1] 杨度华[1] 

机构地区：[1]邢台市疾病预防控制中心,河北邢台市054000 [2]邢台市食品药品监督管理局

出　　处：《热带病与寄生虫学》2015年第3期150-152,共3页Journal of Tropical Diseases and Parasitology

摘　　要：目的：分析2009~2014年邢台市A型H3N2流感病毒流行情况，为科学预防和控制流感提供依据。方法采集2009年6月~2014年5月流感样病例（ILI）的咽拭子标本，采用实时荧光定量PCR方法检测A型H3N2流感病毒核酸，以每年6月至次年5月为监测周期进行统计分析。结果五个监测周期采集ILI咽拭子标本分别为1391、514、643、628和1185份，阳性率分别为6.25%（86/1391）、7.60%（40/514）、0.31%（2/643）、7.32%（46/628）和1.19%（14/1185），不同监测周期阳性率差异有统计学意义（χ2=93.728 P〈0.01）。高峰期主要出现在1、3和9月，每年4~8月未检测到阳性病例。不同年龄组病毒阳性率差异有统计学意义（χ2=44.595，P〈0.01），5~岁年龄组阳性率（7.94%）最高。结论2009~2014年邢台市A型H3N2流感每年均有流行，流行期为当年的9月至次年的3月，高峰期出现在当年的9月至次年的1月。因此为更好防控流感，及时掌握流行趋势，仍需加强监测。Objective To understand the epidemiological tendency of influenza A（H3N2） in Xingtai City from 2009 to 2014 for scientific evidence to prevent and control its spreading. Methods Throat swab specimens were collected between June 2009 and May 2014 from patients presenting with influenza-like illness （ILI）, and subjected to detection of the nucleic acid content of influenza A H3N2 viruses by real-time quantita-tive fluorescence PCR. The surveillance data obtained from June to the following May were statistically ana-lyzed. Results Throat swab specimens obtained in 1 391, 514, 643, 628 and 1 185 cases in respective five sur-veillance cycles were tested, and the positive rates were 6.25%（86/1 391）, 7.60%（40/514）, 0.31%（2/643）, 7.32%（46/628） and 1.19%（14/1 185）, respectively. The positive rate was fluctuated significantly in different cy-cles（χ2=93.728 P〈0.01）, and was dominated by January, March and September, yet the epidemic was free be-tween April and August within a year. The specimens positive for influenza A（H3N2） virus were statistically dif-ferent in different age group（χ2=44.595, P〈0.01）, and highest in the group of five years（7.94%）. Conclusion Influenza A（H3N2） was prevalent in yearly manner in Xintai City from 2009 to 2014, and its epidemic extend-ed from September to following March and peaked between September and following January. However, sur-veillance needs strengthening in order to timely understand the epidemiological trend for scientific control of this communicable disease.

关 键 词：甲型H3N2 流行性感冒 实时荧光定量PCR 

分 类 号：R373.13[医药卫生—病原生物学]