3种邻苯二甲酸酯类塑化剂对大鼠的毒性研究  

Toxicity studies on rats of three phthalic acid ester plasticizers

作　　者：姜莉[1] 耿庆华[1] 于洋[1] 蒋施[1] 

机构地区：[1]沈阳出入境检验检疫局,沈阳110016

出　　处：《沈阳师范大学学报（自然科学版）》2015年第3期432-436,共5页Journal of Shenyang Normal University:Natural Science Edition

基　　金：国家质检总局科技计划项目(2014IK255)

摘　　要：将邻苯二甲酸二乙酯(DEP)、邻苯二甲酸二异丁酯(DiBP)和邻苯二甲酸二异壬酯(DiNP)3种邻苯二甲酸酯类塑化剂分别按每只大鼠每天1/100LD50的剂量连续灌胃染毒20d,染毒后再继续观察20d。实验结束后测量各组大鼠器官与体重的比,结果发现DEP组大鼠的肝脏和3个实验组大鼠卵巢子宫的器体比与对照组有明显差异,其余脏器的器体比均未有明显差异。各实验组大鼠精子畸形率明显高于阴性对照组(P<0.05),各实验组大鼠骨髓嗜多染红细胞微核率虽然高于对照组,但均差异不显著(P>0.05)。各实验组组织病理切片结果显示,3个染毒组大鼠肝、肾、脾均有不同程度的损伤,其余脏器均未发现异常。The rats were exposed to DEP,DiBP and DiNP by oral perfusion at daily 1/100LD50 dose respectively for continous 20 days,then continue to observe 20 days.After the experiment,the ratio of organs to body weight of rats in each group was measured,the results show that,significant differences were found in the ratio of liver to body in DEP group and in the ratio of Ovary uterus to body in the three experimental groups comparing with the blank group,there were no obvious differences found in the other organs.The sperm deformity rate in the experimental groups was significantly higher than that in the negative control group（P0.05）,although the bone marrow micronucleus rate in all experimental groups is higher than that of the blank group,but the difference was not significant（P0.05）.The tissue pathological slices of the experimental groups showed that the liver,kidney and spleen were injured in different degrees in the three exposed groups,no abnormities were found in the other organs.

关 键 词：邻苯二甲酸酯 DEP DIBP DINP 毒性 

分 类 号：R114[医药卫生—卫生毒理学]