脑型脂肪酸结合蛋白在颅脑损伤患者血清中含量检测及意义  

Detection of the serum concentration of brain-type fatty acid binding protein(B-FABP) and its significance in patients of brain injury

作　　者：罗云华 

机构地区：[1]江西省景德镇市第二人民医院,景德镇333000

出　　处：《江西医药》2015年第9期890-892,共3页Jiangxi Medical Journal

摘　　要：目的检测脑型脂肪酸结合蛋白(B-FABP)在脑挫伤患者血清中的含量,探讨其与颅脑损伤严重程度间相关性及临床意义。方法应用ELISA夹心法检测脑挫伤患者、健康志愿者及头皮软组织挫伤患者血清中脑型脂肪酸结合蛋白含量。结果健康志愿者、头皮软组织挫伤患者血清中没有检测出脑型脂肪酸结合蛋白,80例脑挫伤患者血清中共检测出脑型脂肪酸结合蛋白者62例,阳性率77.5%,其中A组(GCS 14-15分)13例,B组(GCS 9-13分)26例,C组(GCS 3-8分)23例。分组阳性率分别为52%、81.3%、100%。三组脑型脂肪酸结合蛋白含量变化与GCS评分值组间比较呈正相关。结论脑挫伤患者血清中脑型脂肪酸结合蛋白含量与脑挫伤严重程度密切相关,可作为临床预测脑挫伤患者严重程度的生化标志物。Objective To detect the concentration of B-FABP in the patients of brain contusion and to evaluate their correlation and significance between severity of head injury and concentration. Methods The serum concentration of B-FABP from 80 patients of brain contusion,50 patients of scalp injury and 10 healthy volunteers were detected by ELISA immune sandwich method. Result No B-FABP was detected in the serum from 10 healthy volunteers and 50 patients of scalp injury,B-FABP were detected in 62 patients of 80 patients of brain contusion,its positive rate was 77.5%;13 was from A group,26 was from B group and 23 was from C group respectively,their corresponding positive rate was 52%,81.3% and 100%,It revealed positive correlation between the serum concentration change of B-FABP and GCS score. conclusion Serum concentration of B-FABP of brain contusion revealed a closed correlation with severity of brain injury,it can be served as a plasma biomarker for predicting severity of brain injury.

关 键 词：脑型脂肪酸结合蛋白 脑挫伤 GCS评分 ELISA夹心法 生化标志物 

分 类 号：R651.15[医药卫生—外科学]