缬沙坦氨氯地平复方制剂治疗原发性高血压伴稳定型心绞痛患者的疗效  

Therapeutic effect of valsartan and amlodipine SPC on primary hypertension with stable angina pectoris

作　　者：王慧[1] 孔晓妮[2] 邹广美[3] 

机构地区：[1]山东工商学院医院综合内科,烟台264005 [2]山东中医药高等专科学校中药系,烟台264110 [3]烟台毓璜顶医院心内科CCU,烟台264000

出　　处：《重庆医科大学学报》2015年第9期1250-1254,共5页Journal of Chongqing Medical University

摘　　要：目的:评价缬沙坦氨氯地平单片复方制剂对原发性高血压伴稳定型心绞痛患者(stable angina pectoris,SAP)的有效性和安全性。方法:将符合条件的122例患者随机分为A组(60例)和B组(62例),A组给予缬沙坦氨氯地平片进行治疗,B组给予缬沙坦氢氯噻嗪片治疗,疗程均为6周。在治疗前后对两组病例的血压、运动平板实验结果、静息心电图、SAP发作状况进行监测同时观察药物不良反应及其依从性。结果:A组治疗后降压疗效优于B组(A组VS.B组,P=0.000;P=0.035)。治疗后运动平板实验结果(P=0.001,P=0.034,P=0.000,P=0.000,P=0.029,P=0.000)、静息心电图改善状况评价(P=0.000)和冠脉事件发作状况(P=0.000),A组与B组相比差异有统计学意义。不良反应监测(P=0.585)及药物依从性评价(P=0.768),A组与B组相比差异无统计学意义。结论:缬沙坦氨氯地平单片复方制剂在更好的实现平稳降压的同时,还能对SAP进行有效遏制,其药物安全性和依从性与其他一线降压药物无差异。Objective：To evaluate the efficacy and safety of valsartan and amlodipine SPC for treating hypertensive patients with stable angina pectoris. Methods：Totally 122 patients were randomly divided into group A （60 cases） and group B （62 cases）. Group A was given valsartan and amlodipine tablets treatment while Group B was given valsartan and hydrochlorothiazide tablets treatment. Both treatments lasted for 6 weeks. The blood pressures, exercise treadmill test results, resting ECG, stable angina pectoris of two groups, before and after the treatment, were monitored and the adverse drug reactions and compliance were observed. Results：The treatment of group A showed better antihypertensive effect than that of group B（group A vs. group B,P=0.000,P=0.035）,and the difference was statistically significant. There were statistical significant differences in exercise treadmill test results （P=0.001 ,P=0.034, P=0.000,P-- 0.000,P=0.029,P=0.000）, resting ECG （P=0.000）, coronary artery events （P=0.000）between group A and group B. There was no significant difference in adverse reactions（P=0.585） and compliance evaluation（P=0.768） of both groups. Conclusion：The treatment based on valsartan and amlodipine tablets is a better treatment in smoothly lowering blood pressure and effectively reducing the stable angina pectoris, sudden coronary events, and there is no significant difference in drug safety and compliance compared with that of the other first-line antihypertensive drugs.

关 键 词：高血压 稳定型心绞痛 药物疗法 复方制剂 缬沙坦氨氯地平 

分 类 号：R541[医药卫生—心血管疾病]