肌动蛋白清除系统与凝血—纤溶系统在子痫前期患者外周血中的变化  

Actin Scavenging System and Coagulation-fibrinolytic System in Peripheral Blood of Pre-eclampsia Patients

作　　者：张岩[1] 刘彤[1] 高漫[1] 梁成波 

机构地区：[1]中国医科大学附属盛京医院妇产科,沈阳110004

出　　处：《中国医科大学学报》2015年第10期926-929,共4页Journal of China Medical University

摘　　要：目的探讨子痫前期患者外周血中凝溶胶蛋白(GSN)、游离维生素D结合蛋白(VDBP)及凝血—纤溶指标的变化与子痫前期发生发展的关系。方法选取子痫前期重度(SPE)、轻度(MPE)患者各30例、同孕龄健康孕妇(对照组1)和足月健康孕妇(对照组2)各30例,比较4组外周血中血浆GSN和游离VDBP的水平,以及凝血指标血小板(PLT)、凝血酶原时间(PT)、活化的部分凝血活酶时间(APTT)、凝血酶时间(TT)、纤维蛋白原(FIB)、D-二聚体(D-dimer)的水平。结果 MPE和SPE组中GSN、VDBP及PLT、PT、APTT、FIB的含量均明显低于对照组1(P<0.05),D-dimer明显高于对照组1(P<0.05)。SPE组中GSN、VDBP及PLT、PT、APTT、FIB的含量明显低于MPE组(P<0.05),D-dimer明显高于MPE组(P<0.05)。在健康孕妇中,对照组1与对照组2相比,随着孕周的增加,GSN水平呈下降趋势,VDBP水平呈上升趋势,均无统计学差异(P>0.05),同时凝血指标均无统计学差异(P>0.05)。结论子痫前期患者外周血中GSN、VDBP水平较健康孕妇显著降低,血液呈病理性高凝状态,且随着病情加重变化更为明显,与孕周关系不大。Objective To detect the levels of plasma gelsolin（GSN）,vitamin D binding protein（VDBP）and coagulation-related parameters in peripheral blood between pre-eclampsia,then analyze their relationships with the onset or development of pre-eclampsia. Methods A total of 30 women with severe pre-eclampsia（SPE）and 30 women with mild pre-eclampsia（MPE）were enrolled for the study and randomly chosen as trial group. 30 normal pregnancies with matching gestational ages were selected as control group-1 and 30 normal full-term pregnancies were randomly chosen as control group-2. The levels of GSN,VDBP,platelet（PLT）,prothrombin time（PT）,thrombin time（TT）,activated partial thromboplastin time（APTT）,fibrinogen（FIB）,and D-dimer were compared between those groups. Results The levels of GSN,VDBP and PLT,PT,APTT,FIB in SPE group were significantly lower than that of MPE group（P〈0.05）,and the level of D-dimer was significantly higher（P〈0.05）. In healthy pregnant women between control group-1 and control group-2,GSN fell during gestational weeks,with a concomitant rise in VDBP with no significance（P〈0.05）. There were no statistical difference among all the levels of coagulation-related parameters in healthy pregnant women（P〉0.05）. Conclusion GSN and VDBP levels in pre-eclampsia are significantly lower than that of normal pregnant women,along with pathological hypercoagulative state,and which are related to severity of disease.

关 键 词：凝溶胶蛋白 维生素D结合蛋白 凝血—纤溶 子痫前期 

分 类 号：R714.25[医药卫生—妇产科学]