黄花蒿内生菌Myrothecium roridum IFB-E091产生的一个新吲哚衍生物  

A new indole derivative from endophyte Myrothecium roridum IFB-E091 in Artemisia annua

作　　者：申丽[1] 李玲玉[1] 张小君[1] 李明[1] 宋勇春[2] 

机构地区：[1]扬州大学医学院,江苏扬州225001 [2]南京大学功能生物分子研究所,江苏南京210046

出　　处：《药学学报》2015年第10期1305-1308,共4页Acta Pharmaceutica Sinica

基　　金：国家自然科学基金资助项目(21372191;31370079)

摘　　要：从黄花蒿内生菌Myrothecium roridum IFB-E091固体发酵产物中分离获得3个化合物,分别被鉴定为:(S)-(-)-N-[2-(3-Hydroxy-2-oxo-2,3-dihydro-1H-indol-3-yl)-ethyl]-acetamide(1)、N-(4-hydroxyphenethyl)acetamide(2)和asperfumoid(3),其中化合物1为新吲哚衍生物。体外细胞毒活性测定表明,化合物1对人肝癌细胞SMMC-7721和人宫颈癌细胞He La没有明显的抑制活性。Three compounds were isolated from solid culture of endophyte Myrothecium roridum IFB-E091 in Artemisia annua. Their structures were determined as （S）-（-）-N-[2-（3-hydroxy-2-oxo-2,3-dihydro-1H-indol- 3-yl）-ethyl]-acetamide （1）, N-（4-hydroxyphenethyl）acetamide （2） and asperfumoid （3）, in which compound 1 was a new indole derivative. In cytotoxicity assay, the compound 1 had no obvious inhibition activity in human hepatoma cell line SMMC-7721 and human cervical carcinoma cell line HeLa.

关 键 词：植物内生菌 Myrothecium roridum 次生代谢产物 结构鉴定 

分 类 号：R284.2[医药卫生—中药学]