线粒体活性氧类及其对心血管系统影响的研究进展  

Research Progress in Mitochondrial Reactive Oxygen Species and Its Effects on Cardiovascular System

作　　者：宋仁生 李涛[2] 吴柱国[1] 

机构地区：[1]广东医学院第二临床医学院,广东东莞523808 [2]广东医学院广东省医学分子诊断重点实验室,广东东莞523808

出　　处：《医学综述》2015年第19期3475-3477,共3页Medical Recapitulate

基　　金：广东医学院科研项目(XB1018)

摘　　要：线粒体是真核细胞中制造能量的机构,其在维持细胞内钙稳态、信号转导以及细胞凋亡中发挥重要作用。当线粒体产生大量活性氧类而无法消除时,可引起线粒体功能障碍,导致细胞死亡和组织损害。线粒体活性氧类在动脉硬化、高血压、心肌缺血/再灌注、心力衰竭等心血管疾病的发生、发展中起重要作用,深入了解线粒体活性氧类与线粒体功能障碍的关系,对更好地理解心血管疾病的发生机制有重要意义。Mitochondria is an important organelle of energy generation in eukaryocytes and plays a pivotal role in cell calcium homeostasis,signal transduction and apoptotic regulation. When a large number of mitochondrial reactive oxygen species cannot be eliminated,it can cause mitochondrial dysfunction,leading to cell death and tissue damage. Numerous studies show that mitochondrial reactive oxygen species play an important role in the pathogenesis of atherosclerosis,hypertension,myocardial ischemia and reperfusion,heart failure etc. Understanding the relationship between mitochondrial reactive oxygen species and mitochondrial dysfunction is of great significance for th better understanding of the mechanisms of cardiovascular disease.

关 键 词：心血管疾病 线粒体 活性氧类 

分 类 号：R54[医药卫生—心血管疾病]