肺炎支原体感染与儿童哮喘相关性的研究进展  

Research Advances in the Correlation between Mycoplasma Infection and Asthma in Children

作　　者：李敏敏[1] 王晓明[1] 

机构地区：[1]复旦大学附属上海市第五人民医院儿科,上海200240

出　　处：《医学综述》2015年第19期3524-3526,共3页Medical Recapitulate

摘　　要：肺炎支原体(MP)是引发社区获得性肺炎的一种常见的致病微生物,多见于儿童和青少年,其与哮喘的发生、急性恶化发作及慢性症状难以控制密切相关。但是,至今支原体感染诱发哮喘的机制尚不明确,可能与MP的直接损伤作用、免疫球蛋白E介导的免疫反应、细胞因子和炎性介质的释放及宿主体质有关。此外,支原体感染引发的哮喘也有自身的特点。总之,两者密切相关,及时检测支原体,预测疗效,调整用药方案非常必要。Mycoplasma pneumoniae（ MP） is a common causative organism of community-acquired pneu-monia in children and young adults,which also has a close relationship with the development,acute exacerba-tion and persistence of chronic difficult-to-control symptom of asthma. However,the mechanisms inducing or causing asthma remain unclear. Possible mechanisms include direct damage of bronchial mucosa,IgE-media-ted immune response,a variety of cytokines,the release of inflammatory mediators and the propensity of host. In addition,asthma caused by infection of MP has its own characteristics. In a word,the occurrence of asthma is closely related to MP infection,therefore it′s necessary to test the mycoplasma,predict the efficacy,and adjust the medication plan.

关 键 词：哮喘 肺炎支原体 儿童 

分 类 号：R725[医药卫生—儿科]