化疗药物治疗双原发肿瘤继发急性白血病1例及文献复习  

One case of double primary tumors with secondary acute leukemia induced by chemotherapy drugs and literature review

作　　者：杨喜晶 周福平 张迁 钱其军 

机构地区：[1]东方肝胆外科医院肿瘤生物治疗科,上海200438

出　　处：《药学实践杂志》2015年第5期453-456,共4页Journal of Pharmaceutical Practice

摘　　要：近年来,随着化疗的大量开展,继发性白血病发病率逐年升高,笔者报道1例卵巢癌并发乳腺癌患者经化疗、放疗后出现急性粒-单细胞白血病,从初次化疗至诊断急性白血病的时间为37个月,起病急、生存期短。文献报道烷化剂、拓扑异构酶I抑制剂、铂类均易诱发继发性白血病。造血干细胞移植可降低病死率、延长无进展生存期。In recent years ,with a large number of chemotherapy development ,the incidence of secondary leukemia in-creased year by year ,an acute myelomonocytic leukemia after chemotherapy and radiotherapy in 1 case of ovarian cancer and breast cancer was reported .The time from first chemotherapy to acute leukemia onset was 37 months .This patient had rapid onset and short survival period .Reports in the literature suggested that alkylating agents ,topoisomerase I inhibitors ,platinum were all easy to induce secondary leukemia .Hematopoietic stem cell transplantation coud reduce mortality and prolong progres-sion free survival .

关 键 词：继发性白血病 卵巢癌 乳腺癌 化疗 

分 类 号：R979.1[医药卫生—药品]