同型半胱氨酸和尿酸水平与不同性别不稳定型心绞痛患者相关性研究  

Correlation Between Homocysteine, Uric Acid Level and Different Gender Patients with Unstable Angina Pectoris

作　　者：吴琳[1] 陈素欣[1] 薛铮[1] 刘星[1] 李洁[1] 吕新湖[1] 

机构地区：[1]河北省石家庄市第一医院心一科,河北石家庄050000

出　　处：《医学临床研究》2015年第9期1691-1693,1698,共4页Journal of Clinical Research

摘　　要：【目的】探讨同型半胱氨酸（Hcy）和尿酸（UA）水平与不同性别不稳定型心绞痛（uAP）患者的相关性。【方法】选择本院住院部收治的UAP患者276例为研究对象，其中男154例（男性UAP组），女122例（女性UAP组）；另外选取160例同期经冠状动脉造影检查冠脉正常的非CHD者为对照组，其中男82例（男性对照组），女78例（女性对照组），对UAP患者发病相关因素进行分析。【结果】男性UAP组和男性对照组在吸烟、高血压病史、高密度脂蛋白胆固醇（HDL—C）、Hcy、维生素B12（VitB12）和叶酸（FA）方面存在显著性差异（P〈0．05～0．01），其它指标两组比较无显著性差异（P〉0．05）；女性UAP组和女性对照组在高血压病史、糖尿病病史、UA、Hcy、VB。z和FA方面存在显著性差异（P〈0．05～0．01），其它指标两组比较无显著性差异（P〉0．05）。Logistic回归分析显示，吸烟、高血压、HDL、Hcy、和VitB12为男性UAP患者发病的独立危险因素（P〈0．05～0．01）；高血压、UA、Hcy、VitB12和FA为女性UAP患者发病的独立危险因素（P〈0．05～0．01）。【结论】血浆Hcy和UA水平为女性UAP独立危险因素，而血浆Hcy水平为男性UAP独立危险因素。[Objective]To investigate the correlation between homocysteine （Hcy）, uric acid （UA） level and different gender patients with unstable angina pectoris （UAP）. [Methods]276 cases of patients with UAP in our hospital were divided into male UAP group （154 cases） and female UAP group （122 cases）. Another 160 cases of people who received coronary angiogram inspection and were diagnosed without coronary heart disease were used as control group, including male control group （82 cases） and female control group （78 cases）. The general data were analyzed. [Results]There were significant difference in smoking, high density lipoprotein cholesterol （HDL）, Hcy, vitamin B12 （Vit B12 ） and folic acid （FA） between male UAP group and male control group （ P 〈0.05 or P 〈0.01）. There were significant difference in high blood pressure, diabetes, UA, Hcy, Vit B12 and FA between female UAP group and female control group （ P 〈0.05 or P 〈0.01）. Logistic regression analysis showed that smoking, high blood pressure, HDL, Hcy and Vit B12 were independent risk factors of male UAP （ P 〈0.05 or P 〈0.01） high blood pressure, UA, Hcy and Vit B12were independent risk factors of female UAP （ P 〈0.05 or P 〈0.01）. [Conclusion]UA and Hey are independent risk factors of female UAP Hcy is independent risk factor of male UAP, not for UA.

关 键 词：半胱氨酸 尿酸 性别因素 心绞痛 不稳定型 危险因素 

分 类 号：R541.42[医药卫生—心血管疾病]