桑黄菌丝体对小鼠肉瘤S_(180)的抑制作用  

Inhibitory Effect of Phellinus igniarius Mycelium on Murine S_(180) Sarcoma

作　　者：雷萍[1] 吴亚召[1] 张文隽[1] 谢艳华[2] 杜芳[1] 

机构地区：[1]陕西省微生物研究所,陕西西安710043 [2]第四军医大学,陕西西安710032

出　　处：《食用菌学报》2015年第3期60-63,共4页Acta Edulis Fungi

基　　金：陕西省科技厅自然科学基础研究计划项目(2013JM3021);陕西省科学院应用基础与产业化项目(2017K-14;2012K-17)资助

摘　　要：建立荷瘤(S180)小鼠模型,用桑黄(Phellinus igniarius)菌丝体灌胃(低、中和高剂量组分别为0.25、0.5和1.0g/kg/d)至模型组肿瘤直径达1cm停止给药,测定抑瘤率和各脏器指数。结果表明:阳性对照组(顺铂3mg/kg/d)显著抑制小鼠体重的增加,而桑黄菌丝体3个剂量组对小鼠体重的增加没有显著的抑制作用;低、中和高3个剂量组抑瘤率分别为18.3%、29.5%和40.7%。桑黄菌丝体对脾脏指数与胸腺指数的影响小于阳性对照药物顺铂。The effects of administering Phellinus igniarius mycelium intragastrically at three dose levels （0.25, 0.5 and 1.0 g/kg/d） to a murine sarcoma S180 model established using the tumor inoculation method have been determined. Mice administered physiological saline or cisplatin （3 mg/kg/d） served as negative and positive controls respectively, and treatments continued until the tumor diameter reached 1 cm. Tumor growth rates were significantly inhibited in mice administered P. igniarius mycelium （18.3%, 29.5% and 40.7% at doses of 0.25, 0.5 and 1.0 g/kg/d, respectively） although the mean weight of animals in each test group was not significantly affected. Compared with negative controls, lower thymus indices were recorded in all the test groups but a lower spleen index was observed only in animals administered the highest dose of mycelium.

关 键 词：桑黄菌丝体 小鼠肉瘤S180 抑瘤作用 

分 类 号：R285[医药卫生—中药学]